Accès ouvert
2026
preprint
OpenAlex
Sawan Patel, Keith Fraser, Dhanush Gandavadi, Abhisek Dwivedy et autres
Abstract Aptamers are single-stranded oligonucleotides that bind molecular targets with high affinity and specificity. However, their discovery remains time-consuming, expensive, and susceptible to experimental biases. Here we present AptaBLE, a deep learning framework for predicting aptamer-protein binding. Additionally, we demonstrate two de …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Meenakshi Ranasinghe, John L. Decker, Keith Fraser, Ying Wang et autres
Abstract In vivo genetic engineering of T cells could overcome the logistical, biological, and safety challenges of ex vivo modification, but effective and safe delivery systems remain limited by a lack of cellular specificity. Here, we developed aptamer-functionalized lipid nanoparticles (LNPs) for …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Abhisek Dwivedy, Dhyanesh Baskaran, Gaurav Sharma, Wei Hong et autres
Abstract The specific and potent delivery of anticancer drugs to targeted cancer stem cells (CSCs) remains a critical need to maximize on‐target, on‐tumor effects while minimizing on‐target, off‐tumor toxicities. Herein, the designer DNA architecture (DDA)‐templated drug conjugates (DDA‐DCs) customized are presented to …
us, Afrique du Sud, Maroc
(code pays fourni par la source)
Accès ouvert
1988
book-review
OpenAlex
Keith Fraser
gb
(code pays fourni par la source)
Accès ouvert
1988
book-review
OpenAlex
Keith Fraser
gb
(code pays fourni par la source)
1988
article
OpenAlex
Moira Munro, Keith Fraser
Data from all 37 admissions under Sections 35, 36 and 38 to two regional Secure Units for the thirty months commencing 1 October 1984 were collected from case records. Some characteristics of these patients were compared with all other admissions and it …
gb, sg
(code pays fourni par la source)