Qianlong Kang

Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate–mediated macrophage reprogramming

Jieping Qiu, Jingwen Wei, Jiaming Liu, Jing Bai et autres

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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer

Y Zhang, Xueyan Zhou, Y Y Wei, Haitao Zhang et autres

Immune checkpoint blockade (ICB) shows limited efficacy in pancreatic ductal adenocarcinoma (PDAC). Here, we demonstrate that ICB-induced IFN-γ signaling upregulates H2-T23 on pancreatic tumor cells, which interacts with NKG2A on NK cells to induce NK cell senescence through activation of p38 MAPK …

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Phonon-polaritonic long-wavelength infrared photodetectors

Qianlong Kang, Anna liu, Shouzheng Jiao, Shuning Liu et autres

Long-wavelength infrared (LWIR) photodetectors are widely used in both military and civilian fields. Compared with traditional LWIR photodetectors, surface plasmon polaritons (SPPs) excited by the coupling of metal microstructures with photons can improve the responsivity and detection dimension of LWIR photodetectors. However, …

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Mesoscopic Behavior of Single-Carrier Avalanche in Narrow-Bandgap Semiconductors

S. Liu, Runzhang Xie, Qianlong Kang, Haonan Ge et autres

The mesoscopic stochasticity of single-carrier avalanche is the dominant factor governing macroscopic noise in narrow-bandgap avalanche photodiodes (APDs). In mercury cadmium telluride (HgCdTe) devices, this randomness induces local electric field fluctuations that trigger gain-limiting band-to-band tunneling (BBT) noise. Traditional macroscopic models inherently …

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Tumor microenvironment heterogeneity and immunotherapy resistance: multidimensional modulation strategies for precision breakthroughs

Yuhao Wei, Renwei Li, Yu Xiang, Huan Tong et autres

The tumor microenvironment (TME) exhibits pronounced spatial and temporal heterogeneity across cancer types, encompassing differences in cellular composition, stromal architecture, and metabolic niches. Rather than being a singular cause, this heterogeneity interacts with tumor-intrinsic mechanisms such as antigen loss and clonal evolution, …

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Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation

Huan Tong, Z. X. Jiang, Linlin Song, Keqin Tan et autres

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

Integrated Single‐Cell and Spatial Transcriptome Reveal Metabolic Gene SLC16A3 as a Key Regulator of Immune Suppression in Hepatocellular Carcinoma

Qianlong Kang, Xiaomeng Yin, Zhenru Wu, Aiping Zheng et autres

ABSTRACT Hepatocellular carcinoma (HCC) is one of the most lethal cancers, usually diagnosed at an advanced stage. Metabolic reprogramming plays a significant role in HCC progression, probably related to immune evasion, yet the key gene is unclear. In this study, six metabolism‐related …

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Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation

Huan Tong, Z. X. Jiang, Linlin Song, Keqin Tan et autres

The effect of the serine/glycine-free diet (-SG diet) on colorectal cancer (CRC) remains unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC patients. Here, we demonstrate that the -SG diet inhibits CRC growth and promotes the accumulation of cytotoxic …

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Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression

Z. X. Jiang, Qianlong Kang, Hong Qian, Zhijie Xu et autres

Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition of this condition is still not well understood. To fill this gap, we analyzed 75,641 cells from cardiac myxoma tissues based …

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Revealing the crucial roles of myxoma cells and CD206+ macrophages in cardiac myxoma progression based on single-cell sequencing.

Z. X. Jiang, Qianlong Kang, Huan Tong, Guangqi Li et autres

e23549 Background: Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition and molecular characteristics of this condition are still not well understood. Methods: We performed single-cell sequencing on cardiac myxoma …

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