Giulia Antognoli

Potentially reversible severe cardiac involvement in thrombotic microangiopathies with malignant hypertension

Marco Allinovi, Silvia Menale, Valentina Querin, Leonardo Caroti et autres

BACKGROUND: Thrombotic microangiopathy (TMA) represents a pathological response to endothelial damage, caused by genetic or acquired factors. It includes conditions like thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome (aHUS), and secondary TMAs. Malignant hypertension can both result from and trigger TMA. This …

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Anti-Rituximab Antibodies Occurrence and Clinical Outcomes in Patients With Primary Membranous Nephropathy

Marco Allinovi, Maxime Teisseyre, Matteo Accinno, Vincent Esnault et autres

Introduction Rituximab is a first-line treatment for primary membranous nephropathy (pMN) with proven efficacy and safety. The use of monoclonal antibodies such as rituximab can lead to the formation of anti-drug antibodies that may interfere with the therapeutic response. In pMN, anti-rituximab …

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Monoclonal gammopathy is present in one fourth of patients undergoing renal biopsy but is pathogenic only in half of them

Marco Allinovi, Lorenzo Aterini, Leonardo Caroti, Giulia Antognoli et autres

BACKGROUND: About 4-7% of renal biopsies show a monoclonal gammopathy-related nephropathy, such as AL amyloidosis, cast nephropathy, or light chain deposition disease. Both a high prevalence and a causal role of monoclonal gammopathy have been observed in patients with C3 glomerulopathy or …

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Severe proteinuria (but not being on dialysis) may be associated with initial inadequate complement inhibition and delayed hematological response to eculizumab therapy

Marco Allinovi, Tommaso Mazzierli, Leonardo Caroti, Giulia Antognoli et autres

Graphical abstract

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An ontology-based approach for modelling and querying Alzheimer’s disease data

Francesco Taglino, Fabio Cumbo, Giulia Antognoli, Ivan Arisi et autres

BACKGROUND: The recent advances in biotechnology and computer science have led to an ever-increasing availability of public biomedical data distributed in large databases worldwide. However, these data collections are far from being "standardized" so to be harmonized or even integrated, making it …

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#6333 LARGE B CELL RENAL INFILTRATION IN A PATIENT WITH WALDESTRöM MACROGLOBULINEMIA: A CASE REPORT

Federica Allegretta, Campolo Gesualdo, Olivieri Antonella, Sarah Ercoletti et autres

Abstract Background and Aims Waldeström Macroglobulinemia (WM) is a clinicopathologic entity demonstrating lymphoplasmacytic lymphoma (LPL) in the bone marrow with an IgM monoclonal gammopathy in the blood. Only 15% of patients with WM may develop a renal insufficiency due to either glomerular …

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#6011 VIRAL INFECTION AND DE NOVO PRODUCTION OF DONOR SPECIFIC ANTIBODIES IN KIDNEY TRANSPLANTATION: DCD VS DBD

Iacopo Gianassi, Jacopo Lomi, Marilú Bartiromo, Lorenzo Di Maria et autres

Abstract Background and Aims Viruses are among the most common causes of opportunistic infection after transplantation and an accurate screening and follow-up is needed in order to prevent related complication as systemic damages and worsening of kidney function. On the other hand, …

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De novo collapsing glomerulopathy after kidney transplantation: Description of two cases

Roberta Cutruzzulà, Selene Laudicina, Alfredo Bagalà, Leonardo Caroti et autres

BACKGROUND: Among different forms of de novo focal segmental glomerulosclerosis (FSGS), which can develop after kidney transplantation (KTx), collapsing glomerulopathy (CG) is the least frequent variant, but it is associated with the most severe form of nephrotic syndrome, histological findings of important …

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Additional file 1 of An ontology-based approach for modelling and querying Alzheimer’s disease data

Francesco Taglino, Fabio Cumbo, Giulia Antognoli, Ivan Arisi et autres

Additional file 1.

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Accuracy of serum PLA2R antibody detected by indirect immunofluorescence in diagnosing biopsy-proven primary membranous nephropathy: a single-center experience and a systematic review of the literature

Marco Allinovi, Gianmarco Lugli, Federica Rossi, Boaz Palterer et autres

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An Ontology-based approach for Modelling and Querying Alzheimer’s Disease Data

Francesco Taglino, Fabio Cumbo, Giulia Antognoli, Ivan Arisi et autres

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Proteinuria selectivity index predicts response to rituximab in adults with minimal change disease and focal segmental glomerulosclerosis

Marco Allinovi, Giorgio Trivioli, Gianmarco Lugli, Maurizio Villanti et autres

The B-cell-depleting antibody rituximab is frequently used in patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), but there are no predictors of response [1]. These are particularly needed in adult patients, given the substantial incidence of ‘secondary’ forms in …

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