A M Isa

Pathophysiological and laboratory aspects of hemostatic disorders in patients with COVID-19

Jelena Đorđević, Olgica Mihaljević, Marijana Stanojević-Pirković, A M Isa et autres

Although coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affects the respiratory system, the possibility of multisystem tissue and organ damage is not excluded. In severe forms of the disease, hematological disorders with the accompanying laboratory …

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A Highly Restricted T-Cell Receptor Dominates the CD8+T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals

Victoria O Kasprowicz, A M Isa, Katie JM Jeffery, Kristina Broliden et autres

Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, …

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Slow Clearance of Human Parvovirus B19 Viremia following Acute Infection

Anna Lindblom, A M Isa, Oscar Norbeck, Susann Wolf et autres

Parvovirus B19 is a common, clinically significant pathogen. Reassessment of the viral kinetics after acute infection showed that the virus is not rapidly cleared from healthy hosts, despite early resolution of symptoms. These findings challenge our current conception of the virus' pathogenesis …

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Adults presenting with acute Parvovirus B19 infection mount sustained activated CD8+ T cell responses - Evidence for ongoing antigen encounter.

Paul Bowness, Victoria O Kasprowicz, A M Isa, Oscar Norbeck et autres

Sustained expansion, activation and maturation of virus-specific CD8+ T cells after acute Parvovirus B19 infection.

Victoria O Kasprowicz, A M Isa, Oscar Norbeck, Thomas Tolfvenstam et autres

Mapping of the Ex Vivo Cellular Immune Response Against the Complete Human Parvovirus B19 Genome During Acute Infection

A M Isa, Oscar Norbeck, Christoph Pöhlmann, Thomas Tolfvenstam

Background: Human parvovirus B19 (B19) is a ubiquitous pathogen, normally causing a mild self‐limiting disease, but also capable of causing both significant pathology and long‐term persistence. The small size and stability of the virus makes it suitable for mapping of the full …

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Immunopotentiating effect of vinca alkaloids on the antibody response to sheep red blood cells in the mouse.

J R Byrd, A M Isa

Evidence is presented that the vinca alkaloids (vinblastine, vincristine, and vindesine) exert an immunopotentiating effect on the antibody response to sheep red blood cells (SRBC). The primary antibody response, measured by the rosette-forming cell (RFC) and hemagglutination (HA) assays, was enhanced by …

P815 mastocytoma-induced rapid shrinkage of the thymus. Abstr.

A M Isa

Inhibition of tumor growth by the vinca alkaloid derivative vindesine sulfate. Abstr.

J Cobbs, A M Isa

Suppressive factors in the ascitic fluids of tumor-bearing mice. Abstr.

A M Isa, C A Parham, B J Foster

T-lymphocyte suppressor activity in the cytotoxic response to the teratocarcinoma 402AX of the mouse.

A M Isa, BILLY RAY SANDERS, C A Parham