Chengze Wu

Nature‐Inspired Chemical Probes for Labeling tRNAs Containing 2‐Thiouridine (s 2 U)

Hongling Zhou, Yuanyuan Li, Jingwen Zhang, Li Wang et autres

RNA modifications play pivotal roles in numerous cellular processes and human diseases. In addition to the well‐studied methyl‐based modifications, hydrophobic prenyl‐modifications have also been found in many RNA species. Herein, a chemical labeling strategy for tagging specific tRNAs by taking advantage of …

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Structural effects of inosine substitution in telomeric DNA quadruplex

Ya Ying Zheng, Ricky Dartawan, Yuhan Wu, Chengze Wu et autres

The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s). Previous studies have demonstrated the implication of G4 in tumor inhibition through chromosome maintenance and manipulation of …

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胰岛素对缺氧大鼠认知损伤的保护作用研究

王飞, 索朗多布杰, Chengze Wu, Xinran Li et autres

目的 探讨胰岛素对高原缺氧所致认知功能损伤的保护作用。方法 从低海拔空运20只大鼠至高原，随机分为4组，高原缺氧组(5只)、吸氧组(5只)、生理盐水组(5只)和胰岛素组(5只)。高原缺氧组大鼠在高原环境中正常饲养，吸氧组大鼠在到达高原后按2 L/h持续给氧3日，生理盐水组大鼠在达到高原后注射生理盐水3次/日，持续3日，胰岛素组大鼠在到达高原后给与胰岛素1.2 U/日，3次/日，持续给药3日。到达高原第4日，对4组大鼠进行Morris水迷宫测试，并观察大鼠大脑HE染色结果。结果 与吸氧组相比，高原缺氧组、生理盐水组和胰岛素组大鼠，穿越平台次数、目标象限所占时间百分比、站立次数和总路程均显著减少(P<0.05)。与高原缺氧组和生理盐水组相比，胰岛素组大鼠，穿越平台次数、目标象限所占时间百分比、站立次数和总路程均显著增加(P<0.05)。结论 高原缺氧可致大鼠学习记忆能力减退，但给与胰岛素后可以减轻大鼠学习记忆能力的减退现象。