Rafik El-Mernissi

Biological Activities and In Silico Molecular Docking of an Aqueous Extract of Nigella sativa L. Seeds: A Focus on Antioxidant, Cytotoxic, and Diuretic Effects

Otmane Zouirech, Rafik El-Mernissi, Mohamed Amine El Hajjaji, Marouane Takie et autres

Background: Nigella sativa L. is a medicinal plant widely recognized for its diverse pharmacological properties. This study aimed to evaluate the antioxidant, diuretic, and cytotoxic effects of an aqueous seed extract and its effects on selected biochemical parameters in rats. The pharmacokinetic …

Maroc, pt, sa, fr (code pays fourni par la source)

Integrated Phytochemical and Pharmacological Investigation of Mentha aquatica L.: Anti‐Inflammatory, Analgesic, and Safety Evidence From In Vivo Studies

Meryem Tourabi, Khaoula Faiz, Rafik El-Mernissi, Bouchra Louasté et autres

ABSTRACT This study investigated the chemical composition, safety profile, and pharmacological activities of a decocted extract from the aerial parts of Mentha aquatica (MA‐DE). High‐performance liquid chromatography with diode‐array detection (HPLC‐DAD) identified several phenolic constituents, mainly hydroxycinnamic and hydroxybenzoic acids. Safety was …

Maroc, pt, sa, Éthiopie, cn (code pays fourni par la source)

Design, synthesis, bioactivity, DFT, and molecular docking of 4-aminoantipyrine analogs as potential analgesic and anti-inflammatory agents

Majda Benabbes, Abderrazzak El Moutaouakil Ala Allah, Oualid Ziraoui, Rafik El-Mernissi et autres

Maroc, pt, tr (code pays fourni par la source)

Antidiabetic Activity of Phenolic‐Rich Extracts From Cistus albidus (L.) in Alloxan‐Induced Diabetic Rats: In Vitro , In Vivo , and In Silico Investigations

Aziz Zouhri, Naoual El Menyiy, Yahya El-Mernissi, Rafik El-Mernissi et autres

ABSTRACT Diabetes, a prevalent metabolic disorder, has prompted extensive research into natural remedies with hypoglycemic potential and minimal side effects. The aim of this study was to examine phenolic compounds using high‐performance liquid chromatography (HPLC). Acute toxicity was assessed in mice following …

Maroc, pt, cn, pk, sa, Soudan du Sud (code pays fourni par la source)

In vitro and in silico antiglycation antihyperglycemic and anti-inflammatory properties of chemically profiled fruit extracts of Solanum obtusifolium Dunal

Rhizlan Abdnim, Mohammed Bouslamti, Rafik El-Mernissi, Ayoub Farihi et autres

This study investigated the phytochemical profile of Solanum Obtusifolium Dunal extract and explored its biological activities, such as antihyperglycemic, antiglycation, and anti-inflammatory properties. Also, it conducted computational analyses, such as molecular docking simulations. Advanced technique, including high-performance liquid chromatography with a diode-array …

bd, Maroc, pt, sa, cn (code pays fourni par la source)

A comparative study on phytochemical analysis and biological properties of three varieties of cannabis sativa L. seeds

Rafik El-Mernissi, Naoual El Menyiy, Aziz Zouhri, Yahya El-Mernissi et autres

Abstract This study evaluated the antioxidant, anti-inflammatory, and analgesic properties of three varieties of Cannabis sativa L. seeds from Morocco, alongside their chemical compositions. High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) were employed for chemical analysis. Antioxidant activity was assessed using …

Maroc, pt, fr, cn, sa, Éthiopie (code pays fourni par la source)

Comparative analysis of phytochemical profile and bioactivities of Cannabis sativa L. organs: insights into α -amylase inhibition, anti-inflammatory activity, antibacterial and antifungal effect

Rafik El-Mernissi, Naoual El Menyiy, Aziz Zouhri, Yahya El-Mernissi et autres

Abstract Cannabis sativa L. has a long history of use in traditional medicine. This study investigates the phytochemical composition and biological activities of the Moroccan “Beldiya” variety. The phytochemical profile was assessed by quantifying polyphenols, flavonoids, and tannins, while Gas Chromatography–Mass Spectrometry …

Maroc, pk, sa, Tchad (code pays fourni par la source)

Unveiling the anti-diabetic potential of Cytisus villosus and Cistus laurifolius through HPLC-based phenolic profiling and multimodal analysis

Aziz Zouhri, Naoual El Menyiy, Yahya El-Mernissi, Rafik El-Mernissi et autres

Abstract Cytisus villosus and Cistus laurifolius , traditionally used in Mediterranean herbal medicine for metabolic disorders, remain insufficiently characterized for their antidiabetic activity. This study investigated polyphenol-rich aqueous extracts using integrated in vitro , in vivo , and in silico approaches. HPLC …

Maroc, pt, cn, sa, Soudan du Sud (code pays fourni par la source)

Comparative Study of Antioxidant and Antimitotic Activities and Quantification of Phenolic Compounds in Three Northern Moroccan Plants

Aziz Zouhri, Yahya El-Mernissi, Rafik El-Mernissi, Amina Labhar et autres

The province of Taounate, located in northern Morocco, is rich in aromatic and medicinal plants (AMPs), including Cistus albidus , Cistus laurifolius , and Cytisus villosus . These botanical species, long revered in local traditional medicine, not only offer a wide range …

pt, Maroc (code pays fourni par la source)

Ethnomedicinal Uses and Antimitotic, Analgesic and Anti-inflammatory Effects of the Aqueous Leaf Extract of Rubus fruticosus L.

Yahya El-Mernissi, Aziz Zouhri, Amina Labhar, Sara Seddoqi et autres

Rubus fruticosus is widely used in traditional medicine for the treatment of pain, inflammation, infections, and metabolic disorders. This study evaluated the biological activities of its aqueous extract using Allium cepa root assay, carrageenan-induced paw edema, and tail flick analgesic models. In …

Maroc, pt (code pays fourni par la source)

Phytochemical diversity of Cymbopogon citratus Stapf volatile compounds and evaluation of their biological properties

Manal Lahyaoui, Naoual El Menyiy, Mansour Sobeh, Nidal Fahsi et autres

Maroc, pt (code pays fourni par la source)

Exploring Moroccan Medicinal Plants: An Ethnobotanical Perspective on Diabetes Management

Yahya El-Mernissi, Aziz Zouhri, Amina Labhar, Naoual El Menyiy et autres

Morocco is a country rich in medicinal plants, many of which have been used for centuries in traditional medicine to treat various ailments, including diabetes. Herbal treatment is often used as an alternative to synthetic drugs because they may be more affordable …

Maroc (code pays fourni par la source)