Kaede Fujita

Sildenafil-associated severe cholestatic drug-induced liver injury presenting as persistent jaundice after stone extraction

Yuma Kamijo, Takanobu Iwadare, Ryoko Endo, Minori Kamata et autres

BACKGROUND: Sildenafil is widely used as a phosphodiesterase type 5 inhibitor for erectile dysfunction. Drug-induced liver injury (DILI) associated with sildenafil is rare, with severe cholestatic cases remaining poorly characterized. A 43-year-old Japanese man was assigned to work in the Philippines two …

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IgA-enriched phenotype predicts liver-related events in MASLD

Takefumi Kimura, Shun‐ichi Wakabayashi, Takanobu Iwadare, Shohei Kondo et autres

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex, multifactorial condition. To achieve truly personalized therapy for MASLD, it will be essential to stratify patients based on clinical and biochemical data by identifying subgroups with distinct disease mechanisms and …

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Baseline and Longitudinal Liver Stiffness Measurement Predict Outcomes in Primary Biliary Cholangitis: A Multicenter Study

Yūki Yamashita, Takefumi Kimura, Kaede Fujita, Taiki Okumura et autres

BACKGROUND & AIMS: Liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE) is a noninvasive tool for assessing severity in primary biliary cholangitis (PBC). While the baseline prognostic value of LSM has been recognized, the clinical significance of longitudinal LSM changes remains …

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Development of a Disaster Welfare Simulation to Enable Policy Consideration

Shintaro Fujita, Kaede Fujita, Junya Tsukamoto, Manabu Ichikawa

Introduction: Japan faces a high risk of disasters, and its aging population has led to an increase in vulnerable individuals, such as the elderly and people with disabilities. During disasters, these individuals often fail to receive adequate support, leading to deteriorating health …

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Analysis of Assessment Information for Evacuation Facilities in the Noto Peninsula Earthquake

Ann Kikuchi, Kaede Fujita, Manabu Ichikawa

Introduction: The Disaster/Digital Information System for Health and Well-being (D24H), fully operational since April 2024, supports health, medical, and welfare teams in disaster-stricken areas by integrating, analyzing, and providing data collected by various teams. During the 2024 Noto Peninsula Earthquake, the system …

Development of a Simulation Model for Disaster Medical Support

Kanae Hori, Kaede Fujita, Junya Tsukamoto, Soichiro Kai et autres

Introduction: Japan frequently experiences natural disasters such as earthquakes and typhoons, and medical support during disasters has become a critical challenge, particularly in a super-aged society. Previous research has utilized simulations to analyze medical resource allocation and Disaster Medical Assistance Teams (DMAT) …

Development of Gaming Simulation for Policy Discussion on the Community-Based Integrated Care System

Kaede Fujita, Manabu Ichikawa

The Community-Based Integrated Care System (CICS) in Japan integrates five key domains—housing, healthcare, long-term care, livelihood support, and prevention—to support elderly’ independent living. However, rising demand for social welfare services and financial constraints challenge its sustainability. Policymaking within CICS requires cross-sectoral coordination, …

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Serum Thrombospondin-2 Predicts Liver-Related Events in Metabolic Dysfunction–Associated Steatotic Liver Disease

Takanobu Iwadare, Takefumi Kimura, Takao Miwa, Yoshiaki Kobayashi et autres

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The Impact of Targeting in Online Advertising on Sales and Advertising Fatigue

Kanae HORI, Kaede Fujita, Manabu Ichikawa

Digital advertising enables precise control over targeting and exposure frequency; however, repeated exposure can induce advertising fatigue and unevenly distribute its burden across consumers. This study develops an agent-based model to investigate how targeting strategies and repeated exposure jointly shape sales outcomes …

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Effect of Dotinurad on Uric Acid and Hepatorenal Parameters in Steatotic Liver Disease: A Pilot Study in Japanese Patients

Yuji Kamijo, Takanobu Iwadare, Takefumi Kimura, Kaede Fujita et autres

Background: Dotinurad (DOT) has demonstrated beneficial metabolic effects in preclinical models as a selective uric acid reabsorption inhibitor. However, its clinical impact on steatotic liver disease (SLD) with hyperuricemia (HU-SLD) remains unclear. Methods: This observational pilot study evaluated 33 patients with HU-SLD …

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Factor Analysis of Evacuation Behavior in Various Disaster Scenarios

Junya Tsukamoto, Kaede Fujita, Manabu Ichikawa

As a precautionary measure against large-scale earthquakes, it is important to understand evacuation destinations and tendencies in the event of a disaster. However, current damage assumptions regarding evacuees are not necessarily sufficient. In particular, problems such as insufficient evacuee support may arise …

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Hepatic angiosarcoma presenting with clinical features of decompensated cirrhosis

Yuji Kamijo, Takanobu Iwadare, Kaede Fujita, Takefumi Kimura et autres

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