Profil bibliographique

Brian B. Haines

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

174Publications signalées

2292Citations signalées

1Affiliations récentes

Les institutions déclarées

Tango Therapeutics (United States)

Les domaines associés

Cancer Immunotherapy and Biomarkersinterferon and immune responsesVirus-based gene therapy researchPI3K/AKT/mTOR signaling in cancerCAR-T cell therapy research

Les publications récentes

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S2 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

TNG917 is a potent, reversible, and selective EHMT1/2 inhibitor.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S5 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

NanoString profiling of knockout lines

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S6 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Summary of the anti-tumor activity of TNG917 in the HT29 CDX huPBMC model

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S6 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Immune profiling in HT29 humanized mouse model

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S8 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

TNG917 plasma pharmaco kinetic parameters

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S7 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Survival analyses of TNG917 +/- anti-PD1 therapy in mouse syngeneic CRC tumor models

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S4 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Antibody panel design for flow cytometry

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S8 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Immune profiling in HT29 humanized mouse model

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S5 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

TNG917 is well tolerated in mouse studies.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S2 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

CRISPR gene score for PDL1 sorting screen

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S1 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

Crystallography data collection and refinement statistics

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S1 from TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Antitumor Immunity and Immunotherapy Efficacy

Alvin Lu, Brian B. Haines, Wenhai Zhang, Minjie Zhang et autres

EHMT1/2 knockout induces a broad interferon signature.

0 citations

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