Accès ouvert
2025
preprint
OpenAlex
Alexander H. Pearlman, Brian J. Mog, Michael S. Hwang, Jordina Rincón-Torroella et autres
Abstract Lethal toxins could become potent therapies against cancer, but their clinical utility is limited by adverse events upon systemic administration. These could be reduced if the toxins were delivered by effector cells that specifically infiltrate cancers, thereby releasing toxins locally into …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jeanne Tie, Yuxuan Wang, Jonathan M. Loree, Joshua D. Cohen et autres
au, us, ca
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Jeanne Tie, Jesse Cohen, Kamel Lahouel, Serigne Lo et autres
au, us
(code pays fourni par la source)
2018
conference-abstract
OpenAlex
M-L. Eich, Simeon Springer, Maria Del Carmen Rodriguez Peña, Diana Taheri et autres
Accès ouvert
2014
article
OpenAlex
Hai Yan, Patrick Killela, Zachary J. Reitman, Yuchen Jiao et autres
BACKGROUND: Malignant cells must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been …
us
(code pays fourni par la source)
2011
conference-abstract
OpenAlex
L. A. Diaz, Yuchen Jiao, Chanjuan Shi, Barish H. Edil et autres
10501 Background: Pancreatic Neuroendocrine Tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia but relatively little is known about the molecular genetics of this disease. Methods: To explore the genetic basis of PanNETs, we determined the exomic sequences of …
2010
conference-abstract
OpenAlex
Kerstin Schmidt, Matthias Holdhoff, Frank Diehl, Philipp Angenendt et autres
3610 Background: Defining adequate resection margins of liver metastasis especially after preoperative chemotherapy is based on empirically determined recommendations and random screening of macroscopic and microscopic tissue sections surrounding the liver metastasis. Mutations are highly specific for tumors and therefore can be …
Accès ouvert
2007
article
OpenAlex
Kristina Lagerstedt‐Robinson, Thalia D. Liu, Jana Vandrovcová, B. Halvarsson et autres
BACKGROUND: Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. …
se, fi, us, fr
(code pays fourni par la source)
Accès ouvert
2004
article
OpenAlex
Long H. Dang, Chetan Bettegowda, Nishant Agrawal, Ian Cheong et autres
Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that C. novyi-NT in combination with anti-microtubule agents can cause the destruction of both the vascular and …
us
(code pays fourni par la source)
2000
article
OpenAlex
Ie‐Ming Shih, Junhui Yu, Tong‐Chuan He, Bert Vogelstein et autres
Inactivation of the adenomatous polyposis coli (APC) gene is a critical event in the development of human colorectal cancers. At the biochemical level, several functions have been assigned to the multidomain APC protein, but the cellular effects of APC expression and how …
2000
article
OpenAlex
Hai Yan, Nikolaos G. Papadopoulos, Giusy Marra, Claudia Perrera et autres
Accès ouvert
1999
article
OpenAlex
Tong‐Chuan He, Timothy A. Chan, B Vogelstein, K. W. Kinzler
PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells. This repression was mediated by beta-catenin/Tcf-4-responsive elements …
us
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