Alejandro Herrero-San Martín

Prognostic Determinants of Presentation and Outcome in Anti-IgLON5 Disease

Lídia Sabater, Mar Guasp, Raquel Ruiz García, Laura Naranjo Rondán et autres

BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is characterized by substantial clinical heterogeneity and variable outcomes. We investigated the associations of clinical features as well as serum neurofilament light chain (NfL), phosphorylated tau (p-tau), IgG4 levels, and the HLA-DRB110:01∼DQB105:01 haplotype with disease presentation and …

es, it, dk, br, fr, at, de, us, ca, be (code pays fourni par la source)

Risk factors and long-term outcomes in SMART syndrome: a multicenter study

Maria Bea Sintes, Gabriel Velilla-Alonso, Alejandro Herrero-San Martín, Jaime Gállego Pérez-Larraya et autres

es (code pays fourni par la source)

Early Treatment With Intravenous Immunoglobulins and Outcomes of Patients With Anti-IgLON5 Disease

Thomas Grüter, Carles Gaig, Yvette S. Crijnen, Maarten J. Titulaer et autres

Importance: Anti-IgLON5 disease is an autoimmune encephalopathy that often leads to severe disability or death. The efficacy of immunotherapy remains unknown. Objective: To investigate whether early immunotherapy is associated with disability and death in anti-IgLON5 disease. Design, Setting, and Participants: This retrospective, …

de, es, nl, at, fr (code pays fourni par la source)

Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease

Carles Gaig, Yaroslau Compta, Anna Heidbreder, Marı́a José Martı́ et autres

BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is a recently described neurologic disease that shares features of autoimmunity and neurodegeneration. Abnormal movements appear to be frequent and important but have not been characterized and are underreported. We describe the frequency and types of movement …

es (code pays fourni par la source)

Expanding the clinical and genetic spectrum of SQSTM1-related disorders in family with personality disorder and frontotemporal dementia

Sara Llamas‐Velasco, Ana Arteche‐López, Antonio Méndez-Guerrero, Verónica Puertas‐Martín et autres

Objective: SQSTM1-variants associated with frontotemporal lobar degeneration have been described recently. In this study, we investigated a heterozygous in-frame duplication c.436_462dup p. (Pro146_Cys154dup) in the SQSTM1 gene in a family with a new phenotype characterized by a personality disorder and behavioral variant …

es, us (code pays fourni par la source)

Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

Paloma Martín‐Jiménez, Mariana I. Muñoz-García, David Seoane, Lucas Roca-Rodríguez et autres

We analyzed the frequency of cognitive impairment (CI) in deceased COVID-19 patients at a tertiary hospital in Spain. Among the 477 adult cases who died after admission from March 1 to March 31, 2020, 281 had confirmed COVID-19. CI (21.1% dementia and …

es (code pays fourni par la source)

Decreased salivary lactoferrin levels are specific to Alzheimer's disease

Marta González‐Sánchez, Fernando Benito Bartolomé, Desireé Antequera, Verónica Puertas‐Martín et autres

BACKGROUND: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients. METHODS: To assess the clinical …

es, us (code pays fourni par la source)

Cognitive impairment is a common comorbidity in COVID-19 deceased patients. A hospital-based retrospective cohort study

Paloma Martín‐Jiménez, Mariana I. Muñoz-García, David Seoane, Lucas Roca-Rodríguez et autres

ABSTRACT Introduction Little is known about the relation of cognitive impairment (CI) to COVID-19 mortality. Here, we analyse the frequency of CI in deceased COVID-19 patients. Methods We included 477 adult cases that died after admission from March 1 to March 31, …

es (code pays fourni par la source)

Correction to: Platelet Proteomic Analysis Revealed Differential Pattern of Cytoskeletal- and Immune-Related Proteins at Early Stages of Alzheimer’s Disease

Marta González‐Sánchez, Teresa Díaz, Consuelo Pascual, Desireé Antequera et autres

es (code pays fourni par la source)

Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients

Marta González‐Sánchez, Javier Jiménez, Arántzazu Narváez, Desireé Antequera et autres

Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. Thus, altered KYNA levels …

es (code pays fourni par la source)

Platelet Proteomic Analysis Revealed Differential Pattern of Cytoskeletal- and Immune-Related Proteins at Early Stages of Alzheimer’s Disease

Marta González‐Sánchez, Teresa Suárez Díaz, Consuelo Pascual, Desireé Antequera et autres

es (code pays fourni par la source)

Amyloid pet in primary progressive aphasia: case series and systematic review of the literature

Alberto Villarejo‐Galende, Sara Llamas‐Velasco, Adolfo Gómez‐Grande, Verónica Puertas‐Martín et autres

es (code pays fourni par la source)