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Anthony Ferranti, Youhyun Noh, Xia Lei, Alexa Richardson et autres
us, ca (code pays fourni par la source)
Alex G. Waterson, Anish Vadukoot, Somnath Jana, Jianwen Cui et autres
Targeted protein degradation can be induced by recruiting a protein of interest to an E3 ligase, resulting in its ubiquitination and subsequent proteasome-mediated degradation. However, only a small number of E3 ligases have been utilized for degradation. Expansion of the repertoire of …
us, ru, sg, de (code pays fourni par la source)
Abiodun S. Oyedele, Somnath Jana, KyuOk Jeon, Navin Vazrala et autres
Abstract Actinoplanes teichomyceticus is a well-established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biological functions of these iron-chelating metabolites remain comparatively underexplored. We identified …
us (code pays fourni par la source)
Aidong Qi, Xueqing Han, Marc Quitalig, Jessica Wu et autres
Schizophrenia is a complex disease involving the dysregulation of numerous brain circuits and patients exhibit positive symptoms (hallucinations, delusions), negative symptoms (anhedonia), and cognitive impairments. We have shown that the antipsychotic efficacy of positive allosteric modulators (PAMs) of both the M4 muscarinic …
us (code pays fourni par la source)
Kwangho Kim, Plamen P. Christov, Ian M. Romaine, Jianhua Tian et autres
Chemical synthesis has been described as a central science. Its practice provides access to the chemical structures of known and/or designed function. In particular, human health is greatly impacted by synthesis that enables advancements in both basic science discoveries in chemical biology …
us (code pays fourni par la source)
Plamen P. Christov, Kwangho Kim, Somnath Jana, Ian M. Romaine et autres
us (code pays fourni par la source)
Ganesha Rai, Daniel J. Urban, Bryan T. Mott, Xin Hu et autres
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been …
us (code pays fourni par la source)
Jennifer R. Kimbrough, Somnath Jana, Kwang-Ho Kim, Alexander Allweil et autres
us (code pays fourni par la source)
Megan E. Dumas, Geng-Yuan Chen, Nicole D. Kendrick, George Xu et autres
us (code pays fourni par la source)
Robert E. Boer, Juan Antonio Giménez‐Bastida, Olivier Boutaud, Somnath Jana et autres
The total synthesis of hemiketal E 2 (HKE 2 ) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE 2 . Synthetic hemiketal E 2 reproduced …
us (code pays fourni par la source)
Rameshu Rallabandi, Somnath Jana, Jon D. Rainier
Abstract The synthesis of the iodohexahydropyridoindolone (II) by NIS promoted cyclization of the dihydropyridone (I) is developed and its conversion to a variety of derivatives including the hydroxy and the anilino derivatives (III) and (VI).
us (code pays fourni par la source)
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