Wangyu Zhao

Negative Cross-Resistance of Pyrethroid-Resistant Aedes aegypti Strains to the Benzimidazolium Derivatives: Virtual Screening, Synthesis, and Bioassay of the Potential Voltage-Gated Sodium Channel Blockers/Modulators

Jiaojiao Luo, Lele Feng, Wangyu Zhao, Ding Li et autres

Negative cross-resistance (NCR) is an effective strategy for managing insecticide resistance. Haedoxan A (HA), a natural insecticide derived from Phryma leptostachya, exhibits NCR with permethrin by targeting voltage-gated sodium channels (VGSCs). In this study, structure-based virtual screening, derivative synthesis, and biological evaluation …

cn, cz, Tunisie (code pays fourni par la source)

Emerging therapeutic potential of glucagon-like Peptide-1 receptor agonists in knee osteoarthritis: a systematic review

Yapeng Li, Lanbo Yang, Feng Li, Jia Fu et autres

Objective: This study aims to systematically investigate the clinical efficacy and mechanisms of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) in the treatment of knee osteoarthritis (KOA), elucidate their underlying mechanisms, and propose potential future research directions. Design: This study followed the …

cn (code pays fourni par la source)

Enzymological and transcriptomic analyses reveal the insecticidal mechanism of 4-propargyloxybenzenesulfonamide as a V-ATPase inhibitor

Wangyu Zhao, Lulu Liu, Yueyao Zhang, Lele Feng et autres

Tunisie, cn (code pays fourni par la source)

Thioacids as precursors for the synthesis of α,α-dideuterio alcohols using mild SmI 2 –D 2 O

Hengzhao Li, Yuqing Zhang, Xinxin Li, Wangyu Zhao et autres

highly reactive acyl radical intermediates, distinguishing it from the SET reduction of carboxylic acids, esters, and amides. The inherent high reactivity of thioacids enables the reaction to proceed under mild conditions, ensuring compatibility with a broad range of sensitive functional groups. With …

cn (code pays fourni par la source)

Highly Chemoselective Synthesis of α, α-Dideuterio Amines by the Reductive Deuteration of Thioamides Using Mild SmI2–D2O

Hengzhao Li, Kemeng Wang, Wangyu Zhao, Xinxin Li et autres

An efficient and chemoselective protocol for the single-electron-transfer (SET) reductive deuteration of thioamides using SmI 2 and D 2 O is reported. This method uniquely produces α,α-dideuterio amines via a thio-ketyl radical intermediate without generating alcohol byproducts, distinguishing it from the SET …

cn (code pays fourni par la source)

Synthesis and insecticidal activities of 4-(propargyloxy) benzenesulfonamide derivatives

Bo Zhou, Lulu Liu, Wangyu Zhao, Lijuan Han et autres

A series of 4-(propargyloxy) benzenesulfonamide derivatives with different substituents on the benzene ring were synthesized and evaluated for their insecticidal activity. Some of the compounds showed good insecticidal activity against Mythimna separata, and the LC50 value of the most active compound B2.5 …

cn (code pays fourni par la source)

Antifungal activity of l ‐azetidine‐2‐carboxylic acid isolated from Disporopsis aspera rhizomes against Podosphaera xanthii

Lijuan Han, Wangyu Zhao, Aijuan Li, Bo Zhou et autres

BACKGROUND: Powdery mildew is one of the fungal diseases commonly occurring in the process of cucurbits protected and open cultivation. Cucumbers, melons and pumpkins are extremely susceptible. The secondary metabolites produced by plants are important sources of fungicides with low toxicity and …

cn (code pays fourni par la source)

Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives

Wangyu Zhao, Chaofu Yang, Lijuan Han, Bo Zhou et autres

In our previous studies, a kind of novel benzenesulfonamides was found to be a candidate insecticidal compounds. It was shown that propargyloxy and sulfonamide groups are pharmacodynamic groups. One hundred and twenty-six (126) naphthalenesulfonamides derivatives with propargyloxy functionality were designed and synthesized, …

cn (code pays fourni par la source)

N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II

Chaofu Yang, Jing Wang, Yunyun Cheng, Yang Xu et autres

cn, cz (code pays fourni par la source)