Bin Hong

DeepHalo: Deep learning-powered exploration of halogenated metabolites uncovering antibacterial depsipeptides

Shanshan Chang, Xin Qi, Mengyuan Wang, Xinyue Huang et autres

In the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration of halogenated metabolites from high-resolution mass spectrometry-based metabolomics. DeepHalo leverages deep …

cn (code pays fourni par la source)

Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster

Y A Li, Jie Fu, Hongmin Sun, Yu Du et autres

Omicsynins are a group of pseudo-tetrapeptides produced by Streptomyces sp. 1647, which exhibited potent anti-influenza A virus and anti-coronavirus activities. However, its biosynthesis mechanism of C-terminus reduction remains unknown. In this work, we explored two short-chain dehydrogenase/reductase (SDR) superfamily encoding genes in …

cn (code pays fourni par la source)

Recent advances on essential fatty acid biosynthesis and production: Clarifying the roles of Δ12/Δ15 fatty acid desaturase

Chen Wu, Bin Hong, Shanshan Jiang, Xue Gang Luo et autres

cn (code pays fourni par la source)

Manipulating osa-MIR156f Expression by D18 Promoter to Regulate Plant Architecture and Yield Traits both in Seasonal and Ratooning Rice

Qing Liu, Yi Rong Su, Yunhua Zhu, Keqin Peng et autres

Abstract Background Rice (Oryza sativa L.) feeds more than half of the world’s population. Ratooning rice is an economical alternative to the second seasonal rice, thus increasing the yield of ratooning rice is highly important. Results Here we report an applicable transgenic …

cn, vn, Égypte (code pays fourni par la source)

[Identification of 3-demethylchuangxinmycin from Actinoplanes tsinanensis CPCC 200056].

Lijie Zuo, Wei Zhao, Zhibo Jiang, Bingya Jiang et autres

Chuangxinmycin (CM) from Actinoplanes tsinanensis was an antibiotic discovered by Chinese scientists about 40 years ago. It contains a new heterocyclic system of indole fused with dihydrothiopyran, whose biosynthetic mechanism remains unclear. CM is used as an oral medicine in the treatment …

MOESM1 of Improving the N-terminal diversity of sansanmycin through mutasynthesis

Yuanyuan Shi, Zhibo Jiang, Xuan Lei, Ningning Zhang et autres

Additional file 1. Table S1. 1H NMR (600 MHz) and 13C NMR (150 MHz) Data for sansanmycin MX-1. Table S2. 1H NMR (600 MHz) and 13C NMR (150 MHz) Data for sansanmycin MX-2. Table S3. 1H NMR (600 MHz) and 13C NMR …

MOESM1 of Improving the N-terminal diversity of sansanmycin through mutasynthesis

Yuanyuan Shi, Zhibo Jiang, Xuan Lei, Ningning Zhang et autres

Additional file 1. Table S1. 1H NMR (600 MHz) and 13C NMR (150 MHz) Data for sansanmycin MX-1. Table S2. 1H NMR (600 MHz) and 13C NMR (150 MHz) Data for sansanmycin MX-2. Table S3. 1H NMR (600 MHz) and 13C NMR …

On Clustered Development of Modern Agriculture in Hunan

Bin Hong

This article talks about the concept and intention of clustery industry of agriculture,and also the effect to improve the competitiveness of agriculture.From the advantage industry,specialty industry,area division of industry,building of agricultural products' brand service levels,it analyzes the present levels and problems of …

cn (code pays fourni par la source)

Expression of scFv-lidamycin fusion protein in Streptomyces globisporus C-1027

Rong‐Guang Shao, Bin Hong

Objective To construct a recombinant strain that can express fusion protein of lidamycin (LDM) and anti-type Ⅳ collagenase single-chain Fv antibody (scFv), and thus to establish a ScFv-LDM with both taretting efficiency and anti-tumor activity. Methods A homologous double crossover vector pBS-scFv …

ru, cn (code pays fourni par la source)

Regulatory mechanism of secondary metabolism in streptomyces

Zhang Yanjuan, Bin Hong

Streptomyces is Gram-positive, filamentous, soil-inhabiting bacteria, which is characterized by the complex morphologloal differentiation and the ability to produce various valuable secondary metabelites, including compounds used as antimicrobial, antiviral, antitumor, antiparasitic and immunosuppressive drags. Them are huge and complicated regulatory networks of …

Construction and characterization of aminopeptidase N deficient Streptomyces lividans TK24

Bin Hong, Yuan Li, Jozef Anné

N terminal degradation has been noted for some homologous and heterologous proteins expressed in Streptomyces lividans , and genes of some aminopeptidases have been cloned Pep N is the one which has broad substrate specificities and the major leucine aminopeptidase activity in …