RET-driven osteoprotegerin expression links medullary thyroid cancer to osteoblastic bone metastases
Rozita Bagheri-Yarmand, Gabriel M. Pagnotti, Joseph L. Kidd, David Ávila Ramírez et autres
Development of bone metastases increases mortality in patients with medullary thyroid cancer (MTC), with ∼50% survival at 5 years after diagnosis, but the underlying mechanisms of action are unknown. We show that patient-derived MTC cells ( RET C634W mutant TT and RET …
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Cell Reports Medicine