Hiroaki Morimoto

[Sequential development of BCR::ABL1-positive chronic myeloid leukemia during treatment of JAK2 V617F-positive essential thrombocythemia].

Midori Goto, Takehiro Higashi, Hiroaki Morimoto, Junichi Tsukada

We report a rare case of JAK2 V617F-positive essential thrombocythemia (ET) followed by BCR::ABL1-positive chronic myeloid leukemia (CML) in a 47-year-old woman. Dasatinib induced deep molecular remission; however, persistent thrombocytosis required hydroxyurea. The persistence of the JAK2 V617F mutation despite BCR::ABL1 suppression …

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Development of Shinkansen Simple Catenary Equipment for Operating Speeds of 320 km/h

Mizuki TSUNEMOTO, Masatoshi Shimizu, Keisuke Irikura, Hiroaki Morimoto et autres

ABSTRACT The compound catenary equipment on the Shinkansen lines currently requires large‐scale renewal. To streamline this process and reduce maintenance costs, an efficient strategy is to replace the compound catenary equipment with simple catenary equipment rather than renewing the compound catenary equipment. …

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Early and Long-Lasting Hematologic Recovery in a Young Adult With Severe Aplastic Anemia Treated With Romiplostim, Horse-Anti-Thymocyte Globulin (ATG), and Cyclosporine A: A Case Report

Eichi Kakizaki, Takehiro Higashi, Kenichi Akao, Hiroaki Morimoto et autres

Aplastic anemia (AA) is a rare but potentially life-threatening bone marrow failure syndrome, typically characterized by peripheral pancytopenia and marked marrow hypocellularity. In acquired cases, immune-mediated destruction of hematopoietic stem cells is the predominant mechanism; however, intrinsic stem cell defects may also …

jp (code pays fourni par la source)

Development of Shinkansen Simple Catenary Equipment for Operating Speeds of 320km/h

Mizuki TSUNEMOTO, Masatoshi Shimizu, Keisuke Irikura, Hiroaki Morimoto et autres

The compound catenary equipment on the Shinkansen lines currently requires large-scale renewal. To streamline this process and reduce maintenance costs, an efficient strategy is to replace the compound catenary equipment with simple catenary equipment rather than renewing the compound catenary equipment. However, …

jp, us (code pays fourni par la source)

231 | IMPACT OF RITUXIMAB EARLY ADMINISTRATION ON OUTCOMES IN ADVANCED STAGE LOW TUMOR BURDEN FOLLICULAR LYMPHOMA: SUBGROUP ANALYSIS OF PHASE III JCOG1411/FLORA STUDY

Noriko Fukuhara, Kenichi Ishizawa, Yusuke Sano, Ryunosuke Machida et autres

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Viral and Fungal Infections Early After HLA-Mismatched Hematopoietic Stem Cell Transplantation Using Low-Dose Antithymocyte Globulin in High-Risk Patients With Hematological Malignancies Not in Remission

Makoto Hirosawa, Tsukasa Nakanishi, Aya Tanaka, Kenichi Akao et autres

BACKGROUND: In vivo T-cell depletion with antithymocyte globulin (ATG), especially at high-doses has been shown to be associated with increased incidence of infections after allogeneic hematopoietic stem cell transplantation (HSCT). However, it remains unclear whether ATG, even at low-doses increases the risk …

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[Successful polatuzumab vedotin and rituximab therapy for post-CAR-T relapse of diffuse large B-cell lymphoma].

T. Kushida, Makoto Hirosawa, Midori Goto, Yoshiko Seike et autres

Relapse or progressive disease after chimeric antigen receptor T-cell (CAR-T) treatment remains a major issue for poor-risk aggressive large B-cell lymphoma. However, limited data are available on post-CAR-T use of polatuzumab vedotin. Here we describe the case of a patient with diffuse …

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Prognostic impact of the UK Myeloma Research Alliance Risk Profile in transplant‐ineligible patients with multiple myeloma who received a melphalan, prednisolone, and bortezomib regimen: A supplementary analysis of JCOG1105

Tomotaka Suzuki, Dai Maruyama, Ryunosuke Machida, Tomoko Kataoka et autres

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Copy Number Alterations of Chromosome 9p24.1 in Elderly Patients with Advanced-Stage Classic Hodgkin Lymphoma Who Received ABVD: An Ancillary Analysis of Multi-Center Retrospective Study in Japan (HORIZON study)

Shinichi Makita, Shigeru Kusumoto, Jun‐ichi Tamaru, Hiroya Hashimoto et autres

Introduction Copy number alterations (CNAs) of chromosome 9p24.1 are frequently observed in patients (pts) with classic Hodgkin lymphoma (cHL), which result in increased expression of programmed death ligand-1 on Reed-Sternberg (RS) cells. The amplification of 9p24.1 was found in approximately 50% of …

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Mogamulizumab for post-transplant relapse of adult T-cell leukemia/lymphoma: a case study

Makoto Hirosawa, Midori Goto, Masahiko Oku, Kenichi Akao et autres

Mogamulizumab (MOG), a humanized monoclonal anti-CCR4 antibody, exerts strong antibody-dependent cellular cytotoxic effects on CCR4-positive adult T-cell leukemia/lymphoma (ATLL) cells. As CCR4 is highly expressed on regulatory T cells as well as ATLL cells, pre-transplant MOG induces severe graft-versus-host disease (GvHD). However, …

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Development of Train Operation Power Simulator Reproducing Commercial Operation

Tomoyuki OGAWA, Yoko TAKEUCHI, Hiroaki Morimoto, Tatsuhito Saito et autres

In recent years, railway companies have been introducing energy-saving technologies. This is leading to a growing need for methods able to accurately estimate the energy-saving effect of individual technologies. To this end, RTRI and JR West have been developing a method to …

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Control Method of DC-DC Converters for High-Voltage Feeding Systems

Tsurugi Yoshii, Hiroaki Morimoto, Takuma Ishiyama, Takayuki Yachida et autres

A high-voltage DC feeding system, which consists of higher-voltage feeders and DC-DC converters in addition to the existing feeding circuit, can be used to supply vehicles power with a conventional feeding voltage. In this system, it is important to consider the control …

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