Alan B. Weder

The Use of Genetic Information in Large-scale Clinical Trials: Applications to Alzheimer Research

Nicholas J. Schork, Alan B. Weder

A great deal of secondary, or covariable, information is often collected during the course of large-scale clinical trials. This information typically includes demographic and anthropometric data but often also includes more elaborate laboratory-based measures that might be used to screen for adverse …

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Effects of Increased Arterial Epinephrine on Insulin, Glucose and Phosphate

Sverre E. Kjeldsen, Andreas Moan, Jurij Pétrin, Alan B. Weder et autres

The relationship between sympathetic nervous system activity and glucose and insulin metabolism is not fully understood. In the present study we therefore investigated the effect of raising arterial plasma epinephrine within the lower pathophysiological concentration range on insulin, glucose and phosphate in …

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Sodium metabolism, hypertension, and diabetes.

Alan B. Weder

The hypertension that frequently accompanies diabetes mellitus is characterized by abnormalities of sodium (Na) metabolism at all physiologic levels: whole-body, renal, and cellular. The most consistently described abnormality is an expansion of exchangeable Na, which seems to be closely associated with increased …

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Does blood pressure reduction necessarily compromise cardiac function or renal hemodynamics? Effects of the angiotensin-converting enzyme inhibitor quinapril

Sverre E. Kjeldsen, Rakesh Gupta, Lisa Krause, Alan B. Weder et autres

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On the asymmetry of biological frequency distributions

Nicholas J. Schork, Alan B. Weder, M. Anthony Schork, D. C. Rao

The long-standing problem of determining whether the skewness in a sample frequency distribution is the manifestation of the intermixing of disparate groups characterizable by a normal mixture distribution or the manifestation of non-mixture, skew-producing determinants is discussed. Biometrical tools for modeling and …

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Brain and the Regulation of Blood Pressure: A Hemodynamic Perspective

Stevo Julius, Alan B. Weder

The central nervous system subserves the homeostasis of the circulation and is organized as a negative feedback system. The following properties of such a feedback system are of interest: a) the setting; b) the range of the regulation; and c) the nature …

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