Amir Horowitz

Bacillus Calmette-Guérin (BCG) and Beyond: Is Systemic Immunotherapy for BCG-Naïve Non–Muscle-Invasive Bladder Cancer Progress or Overreach?

Ashish M. Kamat, Patrick Joseph Hensley, Brigida Anna Maiorano, Roger Li et autres

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A Tumor-Promoting Inflammatory SPP1 + Macrophage–IL6–CRP Axis Drives Immune Dysfunction in Bladder Cancer

Michelle A. Tran, Byuri Angela Cho, Sudeh Izadmehr, Seong‐Keun Yoo et autres

Immune checkpoint blockade (ICB) has revolutionized treatment for urothelial bladder cancer, yet response rates remain limited. Inflammation promotes disease progression and treatment resistance, with macrophages shaping the tumor microenvironment (TME). Although elevated blood C-reactive protein (CRP) is associated with poor clinical outcomes …

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Abstract B060: CMV-induced adaptive NK cell functions to improve bladder cancer patient outcomes

Bérengère Salomé, Igor Duquesne, Amber Barbini, Sonia Domingos Pereira et autres

Abstract INTRODUCTION Intravesical instillation of Bacillus Calmette Guérin (BCG) is the frontline therapy for high grade non-muscle invasive bladder cancer (NMIBC). However, 32-42% of patients experience recurrence and 13% progress to muscle-invasive disease. The immune system is shaped by lifelong virus exposures. …

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Human ISG15 deficiency unveils impaired healing of ulcerations via type I interferon–mediated fibrosis

Christos Sazeides, Lorenzo Cuollo, Ikjot Sidhu, Haley E. Randolph et autres

ISG15 deficiency is a type I interferonopathy characterized by elevated circulating type I interferon (IFN-I), intracranial calcifications, fibrotic skin lesions, and occasionally inflammatory lung disease. However, the mechanisms driving immune-mediated fibrosis remain poorly understood. In this study, we combined molecular biology approaches …

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Multiparametric MRI for Predicting Renal Function Deterioration and Chronic Kidney Disease Development in Patients Undergoing Nephrectomy for Renal Masses: A Pilot Study

M. H. Liu, Octavia Bane, Xin Mu, Haitham Al‐Mubarak et autres

ABSTRACT Background Patients with solid renal masses (SRMs) are at risk of chronic kidney disease (CKD) after surgical resection without a reliable pre‐operative predictor. Purpose To investigate whether pre‐operative multiparametric MRI (mpMRI) can predict CKD development and progression to stage 3 CKD. …

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A monoclonal antibody that recognizes a unique 13-residue epitope in the cytoplasmic tail of HLA-E

Elisha R. Verhaar, Jin Gan, Susan Buhl, Ziao Li et autres

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