Sualeha Riffat

Epidemiological and Clinical Characteristics of COVID-19: A Retrospective Multi-Center Study in Pakistan

Mehmood Ahmad, Bilal Mahmood Beg, Arfa Majeed, Sadaf Areej et autres

The emergence of a pathogen responsible for a mysterious respiratory disease was identified in China and later called a novel coronavirus. This disease was named COVID-19. The present study seeks to determine the epidemiological and clinical characteristics of COVID-19 in Pakistan. This …

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Rasagiline Pharmacokinetics are affected by cytochrome P-450 1A2 genetic variants in different doses

Rabiea Bilal, Naseem Saud, Sualeha Riffat

Rasagiline, a monoamine oxidase-B inhibitor is an alternative monotherapy or add-on therapy with Levodopa for managing Parkinson's disease. The pharmacokinetics of this drug are effected by various environmental factors resulting in therapeutic failure. To explore the effect of genetic variants of cytochrome …

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Evaluation of gender difference in pharmacokinetics of Candesartan cilexetil in the fasted state by RP-HPLC: A single dose comparative study.

Hafiz Awais Nawaz, Muhammad Irfan Masood, Mateen Abbas, Muhammad Usman et autres

), volume of distribution (Vd) and Clearance (CL) were similar in male and female volunteers. No influence of gender was observed on overall pharmacokinetics of candesartan cilexetil. Therefore, no need for dose optimization while administering candesartan cilexetil in male and female patients …

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Development and validation of a chromatographic method for quantification of rasagiline in human plasma

Rabiea Bilal, Muhammad Usman, Abdul Muqeet Khan, Waqas Latif et autres

Purpose: To develop a sensitive, reliable and cost-effective bioanalytical method for the pharmacokinetic analysis of rasagiline in human plasma.Method: Rasagiline was extracted by liquid-liquid extraction method and analyzed by reversed-phase high performance liquid chromatography (HPLC) using a mixture of ammonium acetate (pH …

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Development of paracetamol-caffeine co-crystals to improve compressional, formulation and in vivo performance

Sumera Latif, Nasir Abbas, Amjad Hussain, Muhammad Sohail Arshad et autres

Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. Co-crystals exhibited improved compaction and mechanical behavior. A …

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Polymeric microspheres of okra mucilage and alginate for the controlled release of oxcarbazepine: In vitro & in vivo evaluation

Shazia Akram Ghumman, Sajid Bashir, Sobia Noreen, Abdul Muqeet Khan et autres

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RATIONALIZED AND COMPLEMENTARY FINDINGS OF SILYMARIN (MILK THISTLE) IN PAKISTANI HEALTHY VOLUNTEERS.

Muhammad Ashraf, Farah Abid, Sualeha Riffat, Sajid Bashir et autres

The aim of the work was to examine the influence of gender on pharmacokinetics of silymarin; a basic constituent of medicinal herb "milk thistle" (Silybum marianum). The presented work is the extension of published work of Usman et al. (16). The comparative …

BIOAVAILABILITY AND DISPOSITION KINETICS OF AMOXICILLIN

Zulfiqar-ul- Hassan, Sualeha Riffat, Aamir Nazir, Rahat Naseer et autres

OBJECTIVE: The study was planned to observe the bioavailability anddisposition kinetics of amoxicillin in adult rabbits (irrespective of sex) under healthy anddehydrated conditions. Design: Comparative. Place and duration of study: The study wasconducted at the department of pharmacology, University of Veterinary and …

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Assessment of sex differences in Pharmacokinetics of carvedilol in human.

Mateen Abbas, Abdul Muqeet Khan, Sualeha Riffat, Muhammad Yasin Tipu et autres

Carvedilol is an anti-hypertensive agent capable of blocking both alph (α) and beta (β) receptors used to preclude cardiac arrhythmias and angina. The study was designed to evaluate the Pharmacokinetics of carvedilol in human male and female volunteers. Healthy male and female …

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Bioequivalence study of montelukast tablets in healthy Pakistani volunteers.

Mateen Abbas, Abdul Muqeet Khan, Sadia Amin, Sualeha Riffat et autres

Montelukast is a leukotrien receptor antagonist used for asthma treatment. Objective of this study was to evaluate the bioequivalence of two montelukast 10mg tablets, Innovator drug (Singulair) as reference and other locally manufactured drug (Montiget) in 12 healthy volunteers. It was randomized, …

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A survey of aflatoxin M1 in milk and sweets of Punjab, Pakistan

Asma Sadia, Makhdoom Abdul Jabbar, Youjun Deng, Erum Akbar Hussain et autres

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Bioequivalence Study of Deferiprone In Healthy Pakistani Volunteers

Muhammad Abbas, Abdul Muqeet Khan, Naila Waheed, Sualeha Riffat et autres

The study was conducted to evaluate the bioequivalence of deferiprone 500 mg with innovator drug in Pakistani men. Twenty four healthy volunteers were enrolled in this study. Each volunteer take two tablets of generic and innovator deferiprone with two-week washout period. Blood …