Accès ouvert
2021
article
OpenAlex
Hesham Azizgolshani, Jonathan Coppeta, Else M. Vedula, Elizabeth E. Marr et autres
Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a route to a predictive in vitro model. However, OOC technologies are …
us
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Accès ouvert
2020
article
OpenAlex
Harrson Silva Santana, Marcos R.P. de Souza, Mariana Garcia Mendonça Lopes, Johmar Souza et autres
The SARS-CoV-2 virus, promoter of COVID-19, already infected millions of people around the world, resulting in thousands of fatal victims. Facing this unprecedented crisis in human history, several research groups, industrial companies and governments have been spending efforts to develop vaccines and …
br
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2019
article
OpenAlex
Harrson Silva Santana, Mauri Sérgio Alves Palma, Mariana Garcia Mendonça Lopes, Johmar Souza et autres
Microfluidics and 3D printing will allow a faster research and development in pharmaceutical and medical areas, supporting new solutions for active pharmaceutical production and clinical tests without the necessity of in vivo animal models. The present review aims to show the role …
br
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