Youai Dai

Correction: Interaction between crgA and wc-1b in carotenoid synthesis in Blakeslea trispora

Youai Dai, Renyue Gui, Jingyu Chen, Wei Luo

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Interaction between crgA and wc-1b in carotenoid synthesis in Blakeslea trispora

Youai Dai, Renyue Gui, Jingyu Chen, Wei Luo

β-Carotene is an important pigment widely used in the food industry, and its large-scale production can be achieved using Blakeslea trispora . In B . trispora , CrgA is a key negative regulator of β-carotene synthesis, while Wc-1b is a photoreceptor whose …

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PANoptosis‐Related Optimal Model (PROM): A Novel Prognostic Tool Unveiling Immune Dynamics in Lung Adenocarcinoma

Jianming Peng, Rui Shi Liang, Youai Dai

Background: PANoptosis, a recently characterized inflammatory programmed cell death modality orchestrated by the PANoptosome complex, integrates molecular mechanisms of pyroptosis, apoptosis, and necroptosis. Although this pathway potentially mediates tumor progression, its role in lung adenocarcinoma (LUAD) remains largely unexplored. Methods: Through comprehensive …

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FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in Chronic Obstructive Pulmonary Disease

Weiyu Shen, Zheming Zhang, Youai Dai, Zixiao Zhang et autres

Abstract GPX4 (glutathione peroxidase 4) has recently been reported to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). FSP1 (ferroptosis suppressor protein-1) is a protein that defends against ferroptosis in parallel with GPX4, but its role in …

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Lactobacillus Paracasei JN-8 Produces Genistein and Elicits Anti-Tumor Capacity

Rui Li, Zijie Zhang, Yilin Ren, Yalan Ni et autres

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Clinicopathological analysis of a type of “low grade” poorly cohesive gastric adenocarcinoma not otherwise specified with a good prognosis

Zhiyi Zhou, Dandan Huang, Youai Dai, Yin Yin et autres

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Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling

Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang et autres

Pulmonary hypertension (PH) is characterized by vascular remodeling caused by marked proliferation of pulmonary artery smooth muscle cells (PASMCs). Andrographolide (ANDRO) is a potent anti-inflammatory agent which possesses antioxidant, and has anticarcinogenic activity. The present study examined potential therapeutic effects of ANDRO …

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Periostin

Xiaowei Nie, Chenyou Shen, Jianxin Tan, Zhiyuan Wu et autres

RATIONALE: POSTN (Periostin) is an ECM (extracellular matrix) protein involved in tissue remodeling in response to injury and a contributing factor in tumorigenesis, suggesting that POSTN plays a role in the pathogenesis of pulmonary hypertension (PH). OBJECTIVE: We aimed to gain insight …

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SB203580 protects against inflammatory response and lung injury in a mouse model of lipopolysaccharide‑induced acute lung injury

Gui‐Rong Li, Youai Dai, Jianxin Tan, Jian Zou et autres

Acute lung injury (ALI) is characterized by acute hypoxic respiratory failure, pulmonary edema and inflammatory infiltration. ALI has a high mortality rate (~30%) in the clinical setting; therefore, focusing on the treatment of lung edema and inflammatory responses in ALI is of …

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TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling

Lingpeng Zhu, Wenjuan Wang, Tianhua Xie, Jian Yong Zou et autres

Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus. Abnormal energy metabolism in microvascular endothelium is involved in the progression of diabetic retinopathy. Bile Acid G-Protein-Coupled Membrane Receptor (TGR5) has emerged as a novel regulator of metabolic disorders. However, the …

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PKCγ promotes axonal remodeling in the cortico-spinal tract via GSK3β/β-catenin signaling after traumatic brain injury

Bo Zhang, Zaiwang Li, Rui Zhang, Yaling Hu et autres

Traumatic brain injury (TBI) is a common cause of death and disability. Enhancing the midline-crossing of the contralateral corticospinal tract (CST) to the denervated side of spinal cord facilitates functional recovery after TBI. Activation of the gamma isoform of PKC (PKCγ) in …

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TGR5 Receptor Activation Attenuates Diabetic Retinopathy Through Suppression of RhoA/ROCK Signaling

Lingpeng Zhu, Wenjuan Wang, Tianhua Xie, Jian Yong Zou et autres

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