Romy M. W. de Laat-Kremers

Thrombin generation and thrombin dynamics are associated with recurrent venous thromboembolism after anticoagulation withdrawal

Geke C. Poolen, Romy M. W. de Laat-Kremers, Mark R. Roest, Geert-Jan Geersing et autres

BACKGROUND: Recurrent venous thromboembolism (VTE) is a major concern after stopping anticoagulation. Thrombin generation (TG) parameters-including thrombomodulin (TM) sensitivity-have been proposed as biomarkers of recurrence, but findings remain inconsistent. The role of thrombin dynamic (TD) parameters, including prothrombin conversion and thrombin inactivation, …

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A thrombin-driven neural net diagnoses the antiphospholipid syndrome without the need for interruption of anticoagulation

Romy M. W. de Laat-Kremers, Denis Wahl, Stéphane Zuily, Marisa Ninivaggi et autres

ABSTRACT: Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated with thrombosis. APS is currently diagnosed based on clinical and laboratory criteria, the latter defined as …

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Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation

Romy M. W. de Laat-Kremers, Marisa Ninivaggi, Iris van Moort, Moniek P.M. de Maat et autres

Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot. We measured the dynamics of coagulation in haemophilia A patients by measuring thrombin generation (TG). …

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Vascular activation is a strong predictor of mortality in coronavirus disease 2019 patients on the ICU

Raf De Jongh, Marisa Ninivaggi, Dieter Mesotten, Cui Bai et autres

Respiratory failure in coronavirus disease 2019 (COVID-19) patients is one of the most frequent causes for referral to the ICU. A significant percentage of these patients does not survive the infection due to thromboembolic complications. Furthermore, the vascular system seems also to …

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ST Genesia reference values of 117 healthy donors measured with STG‐BleedScreen, STG‐DrugScreen and STG‐ThromboScreen reagents

Marisa Ninivaggi, Romy M. W. de Laat-Kremers, Audrey Carlo, Bas de Laat

Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement. We aimed to determine reference values and to compare TG in men and women with and …

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Deciphering the coagulation profile through the dynamics of thrombin activity

Romy M. W. de Laat-Kremers, Qiuting Yan, Marisa Ninivaggi, Moniek P.M. de Maat et autres

Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we …

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Towards standardization of thrombin generation assays: Inventory of thrombin generation methods based on results of an International Society of Thrombosis and Haemostasis Scientific Standardization Committee survey

Romy M. W. de Laat-Kremers, Marisa Ninivaggi, Katrien Devreese, Bas de Laat

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Reference values for thrombin dynamics in platelet rich plasma

Qiuting Yan, Marisa Ninivaggi, Bas de Laat, Romy M. W. de Laat-Kremers

Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis. Platelet poor plasma is often used to measure TG, however, …

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