Margarita Y. Komarova

Cultured Myoblasts Derived from Rat Soleus Muscle Show Altered Regulation of Proliferation and Myogenesis during the Course of Mechanical Unloading

Margarita Y. Komarova, Sergey V. Rozhkov, O. A. Ivanova, О. V. Turtikova et autres

The structure and function of soleus muscle fibers undergo substantial remodeling under real or simulated microgravity conditions. However, unloading-induced changes in the functional activity of skeletal muscle primary myoblasts remain poorly studied. The purpose of our study was to investigate how short-term …

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EFFECT OF SIMULATED GRAVITATIONAL UNLOADING ON M. SOLEUS SATELLITE CELLS

Natalia A. Vilchinskaya, S.V. Rozhkov, Margarita Y. Komarova, R.B. Dmitrieva et autres

Markers of the satellite cells terminal differentiation in m. Soleus were analyzed following different periods of gravitational unloading simulated by rats' tail-suspension. Satellite cells were cultivated in vitro. Western blotting was used to determine levels of mTORc1, phospho-p70S6K, phospho-ACC, phospho-FOXO1 and phospho-FOXO3 …

Molecular background of impairments in skeletal muscle of heart failure patients

Oxana Ivanova, Margarita Y. Komarova, Elena Ignatieva, Т. А. Lelyavina et autres

Abstract Background Heart failure (HF) is characterised by systematic inflammation and chronic metabolic dysregulation. HF enhances the release of pro-inflammatory cytokines, induces activation of the complement system, production of autoantibodies, and over-expression of the major histocompatibility (MHC) complex class II molecules. It …

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Transcriptome analysis of skeletal muscles revealed the effect of exercise on the molecular mechanisms regulating muscle growth and metabolism in patients with heart failure

O. A. Ivanova, Elena Ignatieva, Т. А. Lelyavina, В. Л. Галенко et autres

Aim. Heart failure (HF) is accompanied by skeletal muscle atrophy and exercise intolerance. The aim was to study the molecular mechanisms underlying the therapeutic effect of personalized exercise in patients with HF. Material and methods . RNA sequencing obtained from skeletal muscle …

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LMNA Mutations G232E and R482L Cause Dysregulation of Skeletal Muscle Differentiation, Bioenergetics, and Metabolic Gene Expression Profile

Elena Ignatieva, O. A. Ivanova, Margarita Y. Komarova, Н. В. Хромова et autres

gene which include a wide range of neuromuscular disorders. Although lamins are expressed in most types of differentiated cells, LMNA mutations selectively affect only specific tissues by mechanisms that remain largely unknown. We have employed the combination of functional in vitro experiments …

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Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations

Т. А. Lelyavina, В. Л. Галенко, O. A. Ivanova, Margarita Y. Komarova et autres

Heart failure (HF) is associated with skeletal muscle wasting and exercise intolerance. This study aimed to evaluate the exercise-induced clinical response and histological alterations. One hundred and forty-four HF patients were enrolled. The individual training program was determined as a workload at …

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Skeletal Muscle Resident Progenitor Cells Coexpress Mesenchymal and Myogenic Markers and Are Not Affected by Chronic Heart Failure-Induced Dysregulations

Renata I. Dmitrieva, Т. А. Lelyavina, Margarita Y. Komarova, В. Л. Галенко et autres

BACKGROUND AND PURPOSE: In heart failure (HF), metabolic alterations induce skeletal muscle wasting and decrease of exercise capacity and quality of life. The activation of skeletal muscle regeneration potential is a prospective strategy to reduce muscle wasting; therefore, the aim of this …

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ISSLEDOVANIE VLIYaNIYa KhRONIChESKOY SERDEChNOY NEDOSTATOChNOSTI NA FUNKTsIONAL'NYE KhARAKTERISTIKI SKELETNOY MUSKULATURY I REZIDENTNYKh STVOLOVYKh KLETOK MYShEChNOY TKANI

Margarita Y. Komarova, O. A. Ivanova, В. Л. Галенко, Т. А. Lelyavina et autres

SOGLASOVANNAYa REGULYaTsIYa PRO-MIOGENNYKh I PRO-ADIPOGENNYKh SIGNAL'NYKh PUTEY V MIOBLASTAKh LINII S2S12

O. A. Ivanova, Margarita Y. Komarova, Н. В. Хромова, Anna Kostareva et autres