Javier Blázquez Sánchez

Microbiota comparison of individual and pooled cow fecal samples from PEI dairy farms

Ana S. Jaramillo-Jaramillo, J Trenton McClure, Henrik Stryhn, Kapil Tahlan et autres

ca (code pays fourni par la source)

An AI-based pipeline for osteoporosis/osteopenia prediction using hip radiographs

José Acosta Batlle, David Coronado-Gutiérrez, Javier Soto, Jaime Moujir et autres

OBJECTIVE: To develop and validate an artificial intelligence-based tool for the diagnosis of osteoporosis/osteopenia using hip radiographs. The tool aims to classify femurs into risk-based categories for osteoporosis/osteopenia, enabling patient prioritization, enhancing preventive medicine through incidental detection, and assisting clinicians' diagnosis in …

es (code pays fourni par la source)

An automatic AI model for tumoral burden detection and segmentation on whole-body MRI: The DIPCAN study.

Carmen Prieto-de-la-Lastra, Ana Jiménez-Pastor, Anna Nogué Infante, Javier Blázquez Sánchez et autres

e13717 Background: Metastasis dissemination is the main cause of death from cancer, being whole-body magnetic resonance imaging (MRI) a key technology for lesion detection and staging. However, radiological reading is limited by the lack of efficient, accurate tools to automate these tasks, …

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A Model‐Based Approach to Evaluate Anti‐Drug Antibody Impact on Drug Exposure With Biologics: A Case Example With the CD3 T‐Cell Bispecific Cibisatamab

Javier Blázquez Sánchez, Philippe Bernard Pierrillas, Nicolas Frey, Gregor P. Lotz et autres

The administration of biologics can lead to immunogenic responses that trigger anti-drug antibody (ADA) formation. ADAs can decrease drug exposure. A population pharmacokinetic (popPK) model was developed to describe clinical PK data with and without ADA-driven exposure loss with CEA-directed T-cell bispecific …

ch, se, de (code pays fourni par la source)

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

Javier Blázquez Sánchez, Christina Claus, Christine McIntyre, Tamara Tanos et autres

The majority of bispecific costimulatory antibodies in cancer immunotherapy are capable of exerting tumor-specific T-cell activation by simultaneously engaging both tumor-associated targets and costimulatory receptors expressed by T cells. The amount of trimeric complex formed when the bispecific antibody is bound simultaneously …

ch, se, gb (code pays fourni par la source)

Role of sarcopenia in complex abdominal wall surgery: does it increase postoperative complications and mortality?

Ángela Santana Valenciano, Luis Alberto Blázquez Hernando, Álvaro Robín Valle de Lersundi, Javier López‐Monclús et autres

es (code pays fourni par la source)

Lumbar epidural vein thrombosis mimicking disc herniation: A report of 3 cases

Alba Salgado-Parente, Noelia Arévalo Galeano, Nicolás Alejandro Almeida-Aróstegui, Diana Quiñones Tapia et autres

Epidural vein thrombosis is a rare cause of lumbosciatica than can clinically and radiologically mimic other causes of nerve root compression such as disc herniation. We describe 3 unusual cases of spinal epidural plexus vein thrombosis illustrating the difficulty in preoperative diagnosis …

es (code pays fourni par la source)

A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

Mikael Sandell, Anna M. Ericsson, Jonathan Al‐Saadi, Billy Södervall et autres

Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6-12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal …

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Beef Cattle Grazing Native Grasslands May Follow Three Different Supplement Response Patterns

Fiorella Cazzuli, Martí­n Durante, Andrés Hirigoyen, Javier Blázquez Sánchez et autres

Previous studies on winter supplementation of growing cattle grazing stockpiled native Campos grasslands suggest that forage allowance (FA), herbage mass, and weather conditions before and during the supplementation period could all affect supplement feed efficiency (SFE)—that is, the difference or change in …

uy, ar, ca, au, br (code pays fourni par la source)

Quantifying antimicrobial use on Canadian dairy farms using garbage can audits

Landon M. C. Warder, Luke C. Heider, David F. Léger, Daniella Rizzo et autres

Antimicrobial resistance in pathogenic bacteria is one of the preeminent concerns for the future of global health. There is a dose-dependent relationship between antimicrobial use (AMU) and the prevalence of antimicrobial-resistant pathogens. As most AMU in Canada is related to animal agriculture, …

ca (code pays fourni par la source)

Oral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial

Cecilia Suárez Carantoña, Carlos Escobar, M. Fabregate, Monica Lopez Rodriguez et autres

OBJECTIVE: We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan. METHODS: PNIC-Na (NCT03476460) is a phase-2, single-center, randomized, open-label, non-inferiority trial. …

es (code pays fourni par la source)

Supplement feed efficiency of growing beef cattle grazing nativeCamposgrasslands during winter: a collated analysis

Fiorella Cazzuli, Javier Blázquez Sánchez, Andrés Hirigoyen, Pablo Rovira et autres

Abstract Supplementing growing cattle grazing native subtropical Campos grasslands during winter improves the low, even negative, average daily weight gain (ADG) typical of extensive animal production systems in Uruguay. Nonetheless, to render the practice profitable, it is crucial to control supplement feed …

uy, ca, ar, au, br (code pays fourni par la source)