Cuicui Han

SmNAC36 promotes the biosynthesis of bioactive compounds and drought tolerance in Salvia miltiorrhiza

Zheng Zhou, Cuicui Han, Yue Wang, Wenjiao Ma et autres

Although drought stress typically suppresses plant growth and reduces crop yields, mild drought stress paradoxically enhances the accumulation of bioactive compounds such as salvianolic acids and tanshinones in the medicinal plant Salvia miltiorrhiza. However, the regulatory mechanisms that underlie this phenomenon remain …

cn (code pays fourni par la source)

Transcriptomic Insights Into Brassinolide-Mediated Control of Bioactive Compound Biosynthesis in Salvia miltiorrhiza Bunge

Wenjiao Ma, Qi Li, Wenhui Wu, Cuicui Han et autres

Background:Brassinolide (BR) plays a pivotal role in regulating plant secondary metabolism and can promote the accumulation of bioactive compounds. However, relatively few studies have explored the application of BR in Salvia miltiorrhiza, and the mechanistic basis for its function in this context …

cn (code pays fourni par la source)

Research progress on NAC transcription factors in response to drought stress

Cuicui Han, Zheng Zhou, Luyao Yu, Wenhui Wu et autres

With the exacerbation of global climate change, land desertification has become a key factor threatening global food security. Drought stress constrains agricultural production through affecting the geographical distribution patterns of crops, disrupting growth and development processes, and reducing yield and quality. The …

cn (code pays fourni par la source)

CYP98A monooxygenases: a key enzyme family in plant phenolic compound biosynthesis

Zheng Zhou, Yonghao Duan, Yajing Li, Pan Zhang et autres

Abstract Phenolic compounds are derived from the phenylpropanoid metabolic pathways of plants and include phenylpropionic acids, lignins, coumarins, and flavonoids. These compounds are among the most abundant and diverse classes of secondary metabolites found throughout the plant kingdom. Phenolic compounds play critical …

cn (code pays fourni par la source)

Gibberellin-Induced Transcription Factor SmMYB71 Negatively Regulates Salvianolic Acid Biosynthesis in Salvia miltiorrhiza

Cuicui Han, Xingwen Dong, Xiaowen Xing, Yun Wang et autres

Salvia miltiorrhiza, the valuable traditional Chinese medicinal plant, has been used in clinics for thousands of years. The water-soluble salvianolic acid compounds are bioactive substances used in treating many diseases. Gibberellins (GAs) are growth-promoting phytohormones that regulate plant growth and development. Previous …

cn (code pays fourni par la source)

Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway

Siqi Deng, Lu Wang, Shuang Tian, Jiale Wu et autres

cn (code pays fourni par la source)

Design and synthesis of novel mitochondria-targeted ergosterol peroxide derivatives as potential anti-cancer agents

Lu Wang, Shuang Tian, Siqi Deng, Jiale Wu et autres

cn (code pays fourni par la source)

Discovery and Optimization of Ergosterol Peroxide Derivatives as Novel Glutaminase 1 Inhibitors for the Treatment of Triple-Negative Breast Cancer

Ran Luo, Haoyi Zhao, Siqi Deng, Jiale Wu et autres

In this study, novel ergosterol peroxide (EP) derivatives were synthesized and evaluated to assess their antiproliferative activity against four human cancer cell lines (A549, HepG2, MCF-7, and MDA-MB-231). Compound 3g exhibited the most potent antiproliferative activity, with an IC50 value of 3.20 …

cn (code pays fourni par la source)

Acetylation of PGK1 at lysine 323 promotes glycolysis, cell proliferation, and metastasis in luminal A breast cancer cells

Xiuli Gao, Ting Jung Pan, Yu Gao, Wenbin Zhu et autres

BACKGROUND: In prior research employing iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) technology, we identified a range of proteins in breast cancer tissues exhibiting high levels of acetylation. Despite this advancement, the specific functions and implications of these acetylated proteins in …

cn (code pays fourni par la source)

Versatile CYP98A enzymes catalyse meta‐hydroxylation reveals diversity of salvianolic acids biosynthesis

Zheng Zhou, Jingxian Feng, Juncheng Huo, Shi Guang Qiu et autres

Salvianolic acids (SA), such as rosmarinic acid (RA), danshensu (DSS), and their derivative salvianolic acid B (SAB), etc. widely existed in Lamiaceae and Boraginaceae families, are of interest due to medicinal properties in the pharmaceutical industries. Hundreds of studies in past decades …

cn (code pays fourni par la source)

A phase Ib/II, open-label, multicenter study to evaluate the safety, efficacy, and pharmacokinetics/pharmacodynamics of αvβ3/5 integrin and neuropilin-1 targeting peptide LSTA1 in patients with metastatic pancreatic ductal adenocarcinoma.

Jianming Xu, Zuoxing Niu, Yuxian Bai, Wensheng Qiu et autres

e16290 Background: LSTA1, formerly known as CEND-1, is a novel cyclic peptide which selectively binds to αv/β3 and β5 integrins, which are upregulated in solid tumors, where it undergoes protease cleavage producing a C-end rule peptide fragment (CendR) that selectively binds to …

cn, hk (code pays fourni par la source)

Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud

Gang Chen, Tiancheng Ma, Yukun Ma, Cuicui Han et autres

Ent-abietane diterpenoids are the main active constituents of Euphorbia fischeriana. In the continuing search for new anti-breast cancer drugs, 11 ent-abietane diterpenoids (1–11) were isolated from E. fischeriana. The structures of these compounds were clearly elucidated on the basis of 1D and …

cn (code pays fourni par la source)