Yongfang Ding

Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation

Jia Hu, Wenjing Bu, Yongfang Ding, Xin Li et autres

BACKGROUND: Currently, trastuzumab resistance significantly impacts the treatment outcome for individuals with HER2-positive gastric cancer. In clinical practice, Jian Pi Hua Tan Fang (JPHTF) has been shown to be effective in preventing recurrences and metastases caused by gastric cancer. Yet, the treatment …

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Diosmetin‐7‐O‐β‐D ‐glucopyranoside suppresses endothelial–mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis

Huahua Wang, Xiaoyu Zhang, Yangyang Liu, Yunyun Zhang et autres

Diosmetin-7-O-β-D-glucopyranoside (Diosmetin-7-O-glucoside) is a natural flavonoid glycoside known to have a therapeutic application for cardiovascular diseases. Cardiac fibrosis is the main pathological change in the end stage of cardiovascular diseases. Endothelial-mesenchymal transformation (EndMT) induced by endoplasmic reticulum stress (ER stress) via Src …

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Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome

Mingliang Wang, Tingting Qin, Yunyun Zhang, Ting Zhang et autres

Our study established BDL, UUO, and BDL + UUO models, providing a novel idea for analyzing liver and kidney diseases. It is highlighted that the kidney injury accelerated the aggravation of HRS via inflammatory response, which could be protected by inhibiting the …

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Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

Tingting Qin, Mingliang Wang, Ting Zhang, Yingyu Wang et autres

Fibrosis is a worldwide public health problem, which typically results from chronic diseases and often leads to organ malfunction. Chronic inflammation has been suggested to be the major trigger for fibrogenesis, yet mechanisms by which inflammatory signals drive fibrogenesis have not been …

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Sub-acute toxicity of licorice-sargassum extract in Sprague-Dawley rats: biochemical, histopathological, and pharmacokinetic studies

Xinyue Jing, Xian Meng, Zhenhui Wu, Yongfang Ding et autres

Jing, Xinyue1; Meng, Xian2,3,4; Wu, Zhenhui3; Ding, Yongfang4; Peng, Yunru2,3,4; Shen, Mingqing3,4; Wang, Qing5Editor(s): Guo, Lishao Author Information

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基于肠-肝-肾轴的肝纤维化与肾纤维化研究进展

王明亮, Wang Ming-liang, 丁永芳, Yongfang Ding et autres

纤维化是组织受到损伤后, 组织内细胞外基质异常增生和过度沉积的病理过程。各类慢性疾病导致的损伤/炎症是纤维化发生的主要诱因。肝和肾的纤维化是较常见的脏器纤维化。近年来, 肠道微生物群被证明与肝肾相关疾病的发展进程有密切关联, 其内在机制可能与肠道微生物的组成变化以及肠道完整性等相关。肠-肝-肾三者之间通过内分泌和细胞信号通路等各种途径进行相互影响并促进肝和(或)肾纤维化的发展。本文基于肠-肝-肾轴对肝纤维化与肾纤维化的相关研究进展进行综述, 以期为诊疗肝肾纤维化提供新的策略和理论依据。

Effect of sulfur-fumigation process on ginseng: Metabolism and absorption evidences

Hong Shen, Li Zhang, Jin‐Di Xu, Yongfang Ding et autres

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[Effects of total C-21 steroidal glucosides from Cynanchum auriculatum on oxidative stress pathway in mice with liver injury].

Wei Cui, Yunru Peng, Yongfang Ding

The study aimed to investigate the mechanism of hepatoprotective effect of C-21 steroidal glucosides from Cynanchum auriculatum( Baishouwu) on oxidative stress in mice with liver injury. Mice were randomly divided into normal group,model group,positive control group,Baishouwu high group and Baishouwu low group. …

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Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway

Yongfang Ding, Zixuan Peng, Lan Ding, Yunru Peng

Purpose The root of Cynanchum auriculatum Royle ex Wight, known as Baishouwu, has been widely used for a tonic supplement since ancient times. The current study was performed to explore the effect of Baishouwu on the development of experimental hepatocellular carcinoma (HCC) …

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Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum�auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Zhenhui Wu, Yingyu Wang, Xian Meng, Xinjie Wang et autres

Oxidative stress plays an important role in the pathology of liver disorders. Total C‑21 steroidal glycosides (TCSGs), isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, have been reported to exert numerous effects, including liver protective and antioxidant effects. In …

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[Effects of total C-21 steroidal glycosides from Baishouwu on proliferation invasion and apoptosis of human hepatic cancer HepG2 cells].

Zhen-Hui Wu, Xian Meng, Yongfang Ding, Yunru Peng

<0.01). The results suggested that TCSG could inhibit the proliferation and invasion of HepG2 cells, and induce the apoptosis of HepG2 cells. The potential mechanism may be related to the blocking of cell cycle and the regulation of the expressions of apoptosis-related …

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Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway

Linjie Ju, Xiaohua Wen, Chunjun Wang, Yingjie Wei et autres

Aims: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on β-cells …

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