Jens Bollerslev

Prevalence, risk factors and management of bone complications in Cushing's syndrome across Europe. Data from the European Registry on Cushing's syndrome (ERCUSYN)

Aleksandra Zdrojowy-Wełna, Claudia Amaral, Marta Araujo-Castro, Nienke R. Biermasz et autres

OBJECTIVE: The aim of the study was to investigate bone comorbidities and their management in patients included in the European Register on Cushing's syndrome (ERCUSYN). DESIGN: A retrospective multicentric cohort study and on-line survey. METHODS: We analyzed the prevalence of osteoporosis (OP) …

pl, pt, es, nl, no, fr, it, de, bg, pk, il, ru, hr, si, cz, be, se, is, hu, at, lt (code pays fourni par la source)

Management of acromegaly beyond primary surgery: efficacy and safety of repeat surgery and radiotherapy

Shahriar Atai, Markus Wiedmann, Daniel Dahlberg, Jens Bollerslev et autres

INTRODUCTION AND PURPOSE: Re-intervention, either transsphenoidal surgery or radiotherapy, is suggested in patients who are not in remission after primary surgery for acromegaly; however, the evidence is weak. We aimed to assess the remission rate after re-intervention, and complications compared to a …

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ER stress causes variable ACTH production and secretion in corticotroph tumour cells

Merisa Abusdal, Berg Jens Petter, Maria Walewska, Hemaseh Bideli et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours

Kristin Astrid Øystese, Nicoleta Cristina Olarescu, Cecilia Lindskog, Fabjola Xheka et autres

: SOX2, SOX9 and PROP1 were present at low levels in NF-PitNETs. Absence of SOX2 staining was associated with a higher reintervention rate. The stem cell markers correlated positively with markers of gonadotroph differentiation in gonadotroph NF-PitNETs. SOX2 and SOX9 were frequently …

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High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery

Kristina Isand, Richard A. Feelders, Thierry Brue, Miklós Tóth et autres

OBJECTIVE: The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for …

ee, nl, fr, hu, de, cz, es, gb (code pays fourni par la source)

TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours

Anders J. Kolnes, Kristin Astrid Øystese, Evelina Sjöstedt, Nicoleta Cristina Olarescu et autres

PURPOSE: Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-terminal region. …

no, se, lv, de (code pays fourni par la source)

Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

Vincent Amodru, Amandine Ferrière, Antoine Tabarin, Frédéric Castinetti et autres

OBJECTIVE: To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). DESIGN: Cohort study. METHODS: We analyzed 1791 patients with CS, of whom …

es, fr, gr, hu, de, nl, hr, bg, be, se, it, pl, no, pt, tr, ro, us (code pays fourni par la source)

Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?

Ken K. Y. Ho, Maria Fleseriu, Ursula B. Kaiser, Roberto Salvatori et autres

designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinated the Pituitary Neoplasm Nomenclature (PANOMEN) workshop to address the topic. Experts in pituitary developmental biology, …

au, us, fr, br, co, de, jp, gb, es, nl, no, il, se, it (code pays fourni par la source)

TGFBR3L—An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue

Evelina Sjöstedt, Anders J. Kolnes, Nicoleta Cristina Olarescu, Nicholas Mitsios et autres

Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for …

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Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Alexander Kirkeby Eieland, Kjersti Ringvoll Normann, Arvind Y. M. Sundaram, Tuula A. Nyman et autres

Functioning (FCA) and silent corticotroph (SCA) pituitary adenomas act differently from a clinical perspective, despite both subtypes showing positive TBX19 (TPIT) and/or adrenocorticotropic hormone (ACTH) staining by immunohistochemistry. They are challenging to treat, the former due to functional ACTH production and consequently …

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FSH levels are related to E-cadherin expression and subcellular location in non-functioning pituitary neuroendocrine tumours

K. A. Jensen, Berland Øystese Kristin Astrid, Cristina Olarescu, Olivera Casar‐Borota et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

FSH Levels Are Related to E-cadherin Expression and Subcellular Location in Nonfunctioning Pituitary Tumors

Anders J. Kolnes, Kristin Astrid Øystese, Nicoleta Cristina Olarescu, Geir Ringstad et autres

CONTEXT: Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express follicle-stimulating hormone (FSH) and luteinizing hormone (LH) or be hormone negative, but they rarely secrete hormones. During tumor development, epithelial cells develop a mesenchymal phenotype. This process is characterized by decreased membranous E-cadherin and …

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