Hala Kfoury

VEGF-A: A NOVEL MECHANISTIC LINK BETWEEN CYP2C-DERIVED EET AND NOX4 IN DIABETIC KIDNEY DISEASE

Rachel Njeim, Kawthar Braych, Hilda E. Ghadieh, Nadim S. Azar et autres

Diabetes is associated with decreased epoxyeicosatrienoic acids (EET) bioavailability and increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression. We examined whether a soluble epoxide hydrolase (sEH) inhibitor protects against pathologic changes in diabetic kidney disease and whether the inhibition …

VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease

Rachel Njeim, Kawthar Braych, Hilda E. Ghadieh, Nadim S. Azar et autres

Diabetes is associated with decreased epoxyeicosatrienoic acid (EET) bioavailability and increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression. We examined whether a soluble epoxide hydrolase inhibitor protects against pathologic changes in diabetic kidney disease and whether the inhibition of …

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VEGF-A: A NOVEL MECHANISTIC LINK BETWEEN CYP2C-DERIVED EET AND NOX4 IN DIABETIC KIDNEY DISEASE

Rachel Njeim, Kawthar Braych, Hilda E. Ghadieh, Nadim S. Azar et autres

Diabetes is associated with decreased epoxyeicosatrienoic acids (EET) bioavailability and increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression. We examined whether a soluble epoxide hydrolase (sEH) inhibitor protects against pathologic changes in diabetic kidney disease and whether the inhibition …

Comparative analysis of histopathological subtypes of renal cell carcinoma in the Middle East compared to other world regions

Raja B. Khauli, Mark A. Khauli, Nizar Hakam, Mouhamad Al-Moussawy et autres

INTRODUCTION: Renal cell carcinoma (RCC) has various histopathological tumor subtypes which have a significant implication on the oncological outcome of these patients. We aimed to evaluate the distribution of RCC subtypes presenting at a tertiary care center in the Middle East, in …

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Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression

Sufia Husain, Ibrahim Ginawi, Abdelhafiz Ibrahim Bashir, Hala Kfoury et autres

AIM: Focal segmental glomerulosclerosis (FSGS) is a common progressive chronic renal disease. Podocyte injury and loss are the postulated pivotal events that trigger FSGS. In this study, the authors aim to examine the evolution of FSGS in murine models histologically, ultrastructurally and …

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Orbital immature teratoma: A rare entity with diagnostic challenges

Hind M. Alkatan, Omar S. AlObaidan, Hala Kfoury, Yasser H. Al‐Faky

Childhood orbital teratomas are congenital lesions that presents most often at birth with progressive, severe unilateral proptosis. Due to the rarity of such tumors, the diagnosis is often missed with delay in the patient's management. We are presenting a unique case of …

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Toxicity evaluation of methoxy poly(ethylene oxide)- block -poly(ε-caprolactone) polymeric micelles following multiple oral and intraperitoneal administration to rats

Ziyad Binkhathlan, Wajhul Qamar, Raisuddin Ali, Hala Kfoury et autres

Methoxy poly(ethylene oxide)-block-poly(ɛ-caprolactone) (PEO-b-PCL) copolymers are amphiphilic and biodegradable copolymers designed to deliver a variety of drugs and diagnostic agents. The aim of this study was to synthesize PEO-b-PCL block copolymers and assess the toxic effects of drug-free PEO-b-PCL micelles after multiple-dose …

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Biopsy-Proven BK Virus-Associated Nephropathy: Clinico-Pathologic Correlations.

Sarah Jahdali, Noura Al Oudah, Khaled O. Alsaad, Hala Kfoury et autres

OBJECTIVES: Our objective was to study the clinico-pathologic correlations in BK virus nephropathy. MATERIALS AND METHODS: We conducted a retrospective study of all patients with biopsy-proven polyoma (BK) virus infection. We compared their survival and renal outcomes versus BK virus-negative patients with …

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A Case of Pancreatic Adenocarcinoma with Unique Clinical and Unusual Pathological Features

Hala Kfoury

Pancreatic adenocarcinoma is a form of cancer with ominous prognosis which occurs particularly among men above 50 years old with genetic predisposition and environmental and lifestyle risk factors. The incidence is low in patients less than 50 years old. We report a …

The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

Hala Kfoury, Abdulkareem Alsuwaida, Mohammed Alghonaim, Sufia Husain et autres

Background: The concurrence of diabetes and nephritogenic infections may have a tremendous impact on the kidney. The approach to the two concurrent diseases is based on histological, immunofluorescence findings and most importantly on ultrastructural features. In this experiment our aim was to …

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The pathological spectrum associated with the ultrastructural finding of thin glomerular basement membrane: A tertiary medical city experience and review of the literature

Hala Kfoury, Maria Arafah

BACKGROUND: Thin glomerular basement membrane (GBM) has been noted in several glomerular diseases including IgA nephropathy, focal segmental glomerulosclerosis (FSGS), Fabry's disease, and Alport's syndrome. We conducted this study to investigate the pathological ultrastructural spectrum of thin GBMs, to identify associated diseases, …

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Glomerular basement membrane thickness among the Saudi population

Hala Kfoury

The aim of this work was to determine the mean glomerular basement membrane (GBM) thickness in the Saudi population. We calculated the average GBM thickness in patients diagnosed with minimal change disease, and the ultrastructural analysis of at least three glomeruli was …

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