M.B.A. Djamgoz

Bioelectricity, Broadly

M.B.A. Djamgoz, Michael Levin

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A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

Theresa K. Leslie, Aurélien Tripp, Andrew D. James, Scott P. Fraser et autres

Abstract Solid tumours have abnormally high intracellular [Na + ]. The activity of various Na + channels may underlie this Na + accumulation. Voltage-gated Na + channels (VGSCs) have been shown to be functionally active in cancer cell lines, where they promote …

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Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities

M.B.A. Djamgoz, Valerie Jentzsch

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. The standard first-line treatment for PDAC is gemcitabine chemotherapy which, unfortunately, offers only limited chance of a lasting cure. This review further evaluates the hypothesis that the effectiveness of gemcitabine can be improved by …

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Clinical Potential of Nerve Input to Tumors: A Bioelectricity Perspective

Jade A. Phillips, Charlotte Hutchings, M.B.A. Djamgoz

We support the notion that the neural connections of the tumor microenvironment (TME) and the associated 'bioelectricity' play significant role in the pathophysiology of cancer. In several cancers, the nerve input promotes the cancer process. While straightforward surgical denervation of tumors, therefore, …

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Editorial

M.B.A. Djamgoz, Michael Levin

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Meme kanserinde Kv 1.3 ve Kv 10.1 voltaj bağımlı potasyum kanallarının inhibisyonunun oksidatif stres üzerindeki rolü

Didem Turgut Coşan, Çağrı Öner, Ahu Soyocak, Evrim Metcalfe et autres

Amaç: Reaktif oksijen türevleri oksidatif stres, iyonize radyasyon maruziyeti, iskemi-reperfüzyon hasarı ve kanseri içeren fizyolojik ve patolojik durumlarda artmaktadır. Çalışmamızda meme kanser hücrelerinin farklılaşmasında ve çoğalmasında etkili olduğu düşünülen voltaj kapılı potasyum kanallarının inhibisyonunun etkilerini gözlemek amaçlandı. Yöntemler: Farklı karakterlerdeki meme kanseri …

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Ca 2+ and pH – Activated Channels in Pancreatic Ductal Adenocarcinoma (PDAC)

Daniel Sauter, Benedetta Bonito, Markus Rapedius, Andrea Brüggemann et autres

Cl- and K+ channels are involved in several important cellular processes including migration and proliferation. Such processes are commonly dysregulated in cancer. pH and Ca2+ homeostasis are also altered in cancer cells. Thus, the aim of this project was to elucidate the …

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Resveratrol: Inhibitory Effects on Metastatic Cell Behaviors and Voltage-Gated Na+Channel Activity in Rat Prostate Cancer In Vitro

Scott P. Fraser, Alex Peters, Sian Fleming-Jones, Dev Mukhey et autres

Resveratrol, a natural plant phenolic found at high concentration in red grapes, has been suggested to have a range of health benefits. Here, we tested its effects on metastatic cell behaviors. The strongly metastatic rat prostate MAT-LyLu cells were used as a …

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Electrophysiological Characteristics of Neonatal Nav1.5 Expressed in a Highly Invasive Human Breast Cancer Cell Line: Sensitivity to pH and Divalent Cations

M.B.A. Djamgoz, Rustem Onkal

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Ion transport proteins control pancreatic ductal adenocarcinoma

Annemarie Schwab, Cameron Stock, Pawel Swietach, Alžbeta Hulı́ková et autres

Cancer incidence in North Cyprus (1990-2004) relative to European rates.

Evren Hınçal, Bahar Taneri, Ufuk Taneri, M.B.A. Djamgoz

Cancer incidence in North Cyprus (NC), deemed an interesting epidemiological case due to possible contrasting prevailing factors in relation to South and North Europe (SE and NE), was evaluated for the period 1990-2004. Age standardized rates (ASRs) and average age of incidence …

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Pathobiology Of Prostate Cancer: Voltage-gated sodium channel expression and metastatic potential

Senay Yıldırım, Scott P. Fraser, James K.J. Diss, Seyhan Altun et autres

Prostate cancer (PCa) remains the most frequently diagnosed cancer and the second most common cause of death from malignancy in men in the Western world. Despite this, conceptual advances in the understanding of its pathobiology have remained elusive for over half a …