Gail Rauw

Gabapentin increases expression of δ subunit-containing GABAA receptors

Jieying Yu, Dian-Shi Wang, Robert P. Bonin, Antonello Penna et autres

Background Gabapentin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its anticonvulsant, analgesic and anxiolytic properties suggest that it increases GABAergic inhibition; however, the molecular basis for these effects is unknown as gabapentin does not directly modify GABA type …

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Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples

Jennifer N. K. Nyarko, Maa O. Quartey, Ryan M. Heistad, Paul R. Pennington et autres

The serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is thought to alter 5-HT signalling and contribute to behavioural and cognitive phenotypes in depression as well as Alzheimer disease (AD). We explored how well the short (S) and long (L) alleles …

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Neuroactive Steroids and Related Steroids in Autism Spectrum Disorders

Hui Fei Zheng, Wen Qiang Wang, Xin Min Li, Gail Rauw et autres

Neuroactive steroids (rapidly acting steroids that act as allosteric modulators of neurotransmitter receptors such as the É£-aminobutyric acidA (GABAA) receptor and the NMDA glutamate receptor) are involved in brain development and have been proposed to be important in the etiology and/or pharmacotherapy …

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Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

Simon Faissner, Manoj K. Mishra, Deepak Kaushik, Jianxiong Wang et autres

The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally available medications …

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What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels for Environmental Enrichment.

Renee Y. M. Leduc, Gail Rauw, Glen B. Baker, Heather E. McDermid

Environmental enrichment items such as running wheels can promote the wellbeing of laboratory mice. Growing evidence suggests that wheel running simulates exercise effects in many mouse models of human conditions, but this activity also might change other aspects of mouse behavior. In …

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Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

Hui-Fei Zheng, Wenqiang Wang, Xin‐Min Li, Gail Rauw et autres

A review of studies on the body fluid levels of neuroactive amino acids, including glutamate, glutamine, taurine, gamma-aminobutyric acid (GABA), glycine, tryptophan, D-serine, and others, in autism spectrum disorders (ASD) is given. The results reported in the literature are generally inconclusive and …

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Differential efficacy of antiretroviral drugs in HIV-1 infected human microglia

Eugene L. Asahchop, Glen B. Baker, Gail Rauw, Christopher Power

Background: Immune activation in HIV-1-infected patients persists under suppressive antiretroviral treatment and may fuel comorbidities such as atherothrombosis, osteoporosis, metabolic syndrome, neurocognitive disorders and liver steatosis.Our hypothesis was that treated patients present with distinct profiles of immune activation and that each profile …

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The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE)

Travis Musgrave, Curtis A. Benson, Grace Wong, Ikennah Browne et autres

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Tissue concentration changes of amino acids and biogenic amines in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE)

Travis Musgrave, Gustavo Tenorio, Gail Rauw, Glen B. Baker et autres

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Leu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices

A. Amritraj, Gail Rauw, Glen B. Baker, Satyabrata Kar

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Determination of l-serine-O-phosphate in rat and mouse brain tissue using high-performance liquid chromatography and fluorimetric detection

Gail Rauw, Suzanne L. Grant, Viviane Labrie, John Roder et autres

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Zero net flux estimates of septal extracellular glucose levels and the effects of glucose on septal extracellular GABA levels

Desiree L. Krebs‐Kraft, Gail Rauw, Glen B. Baker, Marise B. Parent

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