Santosh Nigam

Involvement of Arachidonic Acid Metabolites in Tumor Growth and Metastasis: Role of Prostacyclin and Thromboxane in Gynecological and Gastrointestinal Cancer of Humans

Santosh Nigam, Ulrich Rosendahl, Chiara Benedetto

Prostaglandins are tissue hormones comprising groups of polyunsaturated and hydroxylated long-chain fatty acids which exert different biological actions at very low concentrations. PGI2, a major product of arachidonic acid metabolism in isolated vascular tissue, dilates blood vessels and is a powerful inhibitor …

Hepoxilin A3 protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid

Maria‐Patapia Zafiriou, Laura C. Zelarayán, Claudia Noack, Anke Renger et autres

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Revealing yeast spore movement in confined space

Lodewyk Kock, C STRAUSS, EE Pretorius, Carolina H. Pohl et autres

OME YEASTS PRODUCE SEXUAL SPORES (ascospores) in a variety of shapes and surface ornamentations.These intriguing structures have hitherto been used only in yeast classification.Here, we propose the likely primary function of spore shape and ornamentations, in water-driven movement, as aiding the dispersal …

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C. albicans activates cyclooxygenase but not its product prostaglandin E2 in HPV 16-stabilized cells

Rupal Deva, Marco Sczepanski, Sipra Saha, Maria‐Patapia Zafiriou et autres

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On Mechanism of Quorum Sensing in Candida albicans by 3(R)-Hydroxy-Tetradecaenoic Acid

Santosh Nigam, Roberto Ciccoli, Igor Ivanov, Marco Sczepanski et autres

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Inhibition of Lipoxygenase Products by Retinoids in Human Blood Cells

Santosh Nigam

Arotinoids, third generation retinoids, inhibited significantly 12-lipoxygenase in platelets and 5-lipoxygenase in human neutrophils. The doses required for inhibition of 12-lipoxygenase in platelets were as low as 1 pM and of 5-lipoxygenase in neutrophils as low as 100 pM. No cytotoxicity was …

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Prostaglandin E 2 Promotes Hypotension on Low-Sodium Hemodialysis

G. Schultze, Mahamane Kalil Maïga, Hans‐Hellmut Neumayer, Karl Wagner et autres

The influence of low-sodium dialysate (126 mmol/l) on plasma levels of prostaglandin E2 (PGE2) and PGF2 alpha, plasma renin activity (PRA) and arterial blood pressure was investigated in 16 patients on maintenance hemodialysis. PGE2 rose more than tenfold and there was a …

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Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide

Luciano De Petrocellis, Rupal Deva, Francesco Mainieri, Michael Schaefer et autres

The fungal pathogen Candida albicans transforms arachidonic acid (AA) into 3-hydroxyarachidonic acid [3R-HETE], and we investigated if its nonpathogenic and 3R-HETE-producing close relative, Dipodascopsis uninucleata, could similarly transform the endocannabinoid/endovanilloid anandamide into 3-hydroxyanandamide (3-HAEA). We found that D. uninucleata converts anandamide into …

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Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form

Santosh Nigam, Maria‐Patapia Zafiriou, Rupal Deva, Nadja Kerstin et autres

Non-bullous congenital ichthyosis erythroderma (NCIE) and lamellar ichthyosis (LI) are characterized by mutations in 12R-lipoxygenase (12R-LOX) and/or epidermal lipoxygenase 3 (eLOX3) enzymes. The eLOX3 lacks oxygenase activity, but is capable of forming hepoxilin-type products from arachidonic acid-derived hydroperoxide from 12R-LOX, termed 12R-hydroperoxyeicosa-5,8,10,14-tetraenoic …

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Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

Eric J. Haas-Stapleton, Yan Lü, Song Hong, Makoto Arita et autres

Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from omega-3 polyunsaturated fatty acids (PUFA) that attenuate neutrophil migration during the resolution …

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Biological role of hepoxilins: Upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?

Maria Patapia Zafiriou, Rupal Deva, Roberto Ciccoli, Athanassia Siafaka‐Kapadai et autres

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Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon

Angelo A. Izzo, Gabriella Aviello, Stefania Petrosino, Pierangelo Orlando et autres

Colorectal cancer is an increasingly important cause of death in Western countries. Endocannabinoids inhibit colorectal carcinoma cell proliferation in vitro. In this paper, we investigated the involvement of endocannabinoids on the formation of aberrant crypt foci (ACF, earliest preneoplastic lesions) in the …

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