Wen Peng

Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes

Rajiv Agarwal, Wanzhu Tu, Alfredo E. Farjat, Youssef M.K. Farag et autres

BACKGROUND: In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular and kidney failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates cardiovascular and kidney …

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Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium–Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis

Peter R Rossing, Stefan D. Anker, Gerasimos S Filippatos, Bertram Pitt et autres

OBJECTIVE: Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium-glucose cotransporter 2 inhibitors (SGLT2is) …

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Ischemia-Modified Albumin As A Marker For Acute Aortic Dissection: A Prospective Observational Study

Yang Zhou, Xiangping Chai, Huaping He, Wen Peng et autres

Abstract Background: Delayed or misdiagnosed aortic dissection can lead to death and morbidity. Ischemia-modified albumin (IMA) measures the cobalt binding capability and has been associated with mortality in patients with acute aortic dissection (AAD). However, it is unknown whether IMA levels can …

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High-resolution melting curve analysis for rapid detection of Isoniazid-resistant Mycobacterium tuberculosis in Qinghai Province

Yuanyuan Zhang, Zhaofen Wang, Bin Li, Wen Peng et autres

Objectives: To evaluate the diagnostic value of high-resolution melting curve (HRM) analysis to isoniazid-resistant Mycobacterium tuberculosis (MTB) derived from patients on the Qinghai-Tibet Plateau, compared with DNA sequencing. Methods: A total of 96 clinical isoniazid (INH) resistant isolates, determined by drugs susceptibility …

The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity

Yao-xue Guo, Xue Fei Xu, Qi Zhi Zhang, Li Chun et autres

Co-treatment of isoniazid (INH) and rifampicin (RFP) is well known for clinically apparent liver injury. However, the mechanism of INH/RFP-induced liver injury is controversial. Emerging evidence shows links between inhibition of bile acids transporters and drug-induced liver injury (DILI). The present study …

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