Neville Finch

ChemInform Abstract: TOXICOLOGICAL CONSIDERATIONS FOR THE MEDICINAL CHEMIST

Neville Finch

Toxicological considerations for the medicinal chemist

Neville Finch

Synthesis and antihypertensive activity of 5-amino-2-pyridinecarboxylic acid derivatives

Neville Finch, Thomas R. Campbell, Charles W. Gemenden, Henry J. Povalski

The synthesis of various substituted 5-amino-2-pyridinecarboxylic acids and their derivatives is described by three general methods: (1) reductive alkylation of methyl 5-amino-2-pyridinecarboxylates (2) and subsequent hydrolysis; (2) alkylation of the urethane (9), followed by hydrolysis; and (3) selective NaBH4 reduction of the …

Syntheses of 1,2,4-benzothiadiazine 1-oxides and 1,2,4-benzothiadiazines

Neville Finch, S. Ricca, Lincoln H. Werner, Ronald K. Rodebaugh

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of 1,2,4-benzothiadiazine 1-oxides and 1,2,4-benzothiadiazinesNeville Finch, Salvatore Ricca Jr., Lincoln H. Werner, and Ronald RodebaughCite this: J. Org. Chem. 1980, 45, 17, 3416–3421Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01305a009https://doi.org/10.1021/jo01305a009research-articleACS PublicationsRequest reuse …

Synthesis of [5.1]metacyclophane

Neville Finch, Charles W. Gemenden

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of [5.1]metacyclophaneNeville Finch and Charles W. GemendenCite this: J. Org. Chem. 1979, 44, 15, 2804–2805Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/jo01329a048https://doi.org/10.1021/jo01329a048research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the …

Synthesis and antihypertensive activity of 5-thio-2-pyridinecarboxylic acid derivatives

Neville Finch, Thomas R. Campbell, Charles W. Gemenden, Michael J. Antonaccio et autres

Synthesis of various substituted 5-thio-2-pyridinecarboxylic acids and their derivatives is described by three methods, i.e., displacement of nitrite from methyl 5-nitro-2-pyridinecarboxylate (10) by a thiol anion, alkylation of methyl 5-thio-2-pyridinecarboxylate derived from reaction of the diazotized methyl-5-amino-2-pyridinecarboxylate (5) with thiocyanate followed by …

A reinvestigation of the synthesis of cis-1,2,3,4,4a,10a-hexahydro[1,4]benzodioxino[2,3-c]pyridine and a synthesis of meso-2,3,4,5,5a,11a-hexahydro-1H-[1,4]benzodioxino[2,3-d]azepine

Neville Finch, Louis A. Blanchard, Lincoln H. Werner

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA reinvestigation of the synthesis of cis-1,2,3,4,4a,10a-hexahydro[1,4]benzodioxino[2,3-c]pyridine and a synthesis of meso-2,3,4,5,5a,11a-hexahydro-1H-[1,4]benzodioxino[2,3-d]azepineNeville Finch, Louis Blanchard, and L. H. WernerCite this: J. Org. Chem. 1977, 42, 24, 3933–3937Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November …

Synthesis of 4,4,9,17-tetramethyl-2,6-dithia[7.1]paracyclophane and isolation of atropisomeric forms of the tetraoxide

Neville Finch, Charles W. Gemenden, B.P. Korzun

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 4,4,9,17-tetramethyl-2,6-dithia[7.1]paracyclophane and isolation of atropisomeric forms of the tetraoxideNeville Finch, Charles W. Gemenden, and Bernard P. KorzunCite this: J. Org. Chem. 1976, 41, 15, 2509–2514Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July …

Synthesis of 2-methyl and 2-phenyl-5-thiopyridines

Neville Finch, Charles W. Gemenden

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-methyl and 2-phenyl-5-thiopyridinesNeville Finch and C. W. GemendenCite this: J. Org. Chem. 1975, 40, 5, 569–574Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/jo00893a006https://doi.org/10.1021/jo00893a006research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views …

Total synthesis of dl-9-deoxyprostaglandin E1

Neville Finch, John J. Fitt, Iva Hsiu-Chu. Hsu

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of dl-9-deoxyprostaglandin E1Neville Finch, John J. Fitt, and Iva H. S. HsuCite this: J. Org. Chem. 1975, 40, 2, 206–215Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/jo00890a012https://doi.org/10.1021/jo00890a012research-articleACS PublicationsRequest reuse permissionsArticle Views1264Altmetric-Citations61LEARN …

Synthesis of 1,3,4,5,6,7,8,8a-octahydro-2-methyl-4a-phenylisoquinolin-6-ols. Novel fragments of the morphine molecule

Neville Finch, Louis A. Blanchard, R. T. Puckett, Lincoln H. Werner

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1,3,4,5,6,7,8,8a-octahydro-2-methyl-4a-phenylisoquinolin-6-ols. Novel fragments of the morphine moleculeNeville Finch, Louis Blanchard, R. T. Puckett, and L. H. WernerCite this: J. Org. Chem. 1974, 39, 8, 1118–1124Publication Date (Print):April 1, 1974Publication History Published online1 May 2002Published inissue 1 April …

Total synthesis of DL-prostaglandin E1

Neville Finch, Laurence DellaVecchia, John J. Fitt, Ralph A. Stephani et autres

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of DL-prostaglandin E1Neville Finch, L. DellaVecchia, John J. Fitt, Ralph Stephani, and I. VlattasCite this: J. Org. Chem. 1973, 38, 26, 4412–4424Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://pubs.acs.org/doi/10.1021/jo00965a014https://doi.org/10.1021/jo00965a014research-articleACS PublicationsRequest reuse …