L M McEvoy

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study

Tessa Kole, Edward Vanden Berghe, Monica Kraft, Judith M. Vonk et autres

Background Persistent airflow limitation (PAL) occurs in a subset of patients with asthma. Previous studies on PAL in asthma have included relatively small populations, mostly restricted to severe asthma, or have no included longitudinal data. The aim of this post-hoc analysis was …

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IL-17–high asthma with features of a psoriasis immunophenotype

Jörgen Östling, Marleen van Geest, James P. R. Schofield, Zala Jevnikar et autres

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Stratification of asthma phenotypes by airway proteomic signatures

James P. R. Schofield, Dominic W. Burg, Ben Nicholas, Fabio Strazzeri et autres

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Membrane Phospholipid Asymmetry and the Adherence of Loaded Red Blood Cells

Robert Schlegel, L M McEvoy, Philip T. F. Williamson

The phospholipids of the red cell membrane are asymmetrically distributed across the bilayer. Loss of this asymmetry by certain normal and pathological red cells is correlated with their increased adherence both in vitro and in vivo. Red cells loaded under conditions which …

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Non-viral delivery of nuclear factor-κB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis

Christopher G. De Vry, Srinivasa R. Prasad, László G. Kömüves, Carlos Lorenzana et autres

BACKGROUND: Nuclear factor-kappaB (NF-kappaB) is a key transcriptional regulator of inflammatory bowel disease (IBD). AIM: To investigate the therapeutic potential of a locally administered "non-viral" nuclear factor-kappaB decoy (NFkappaBD) in multiple experimental models of IBD. METHODS: A fully phosphorothioated decoy oligonucleotide with …

The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules

R. Aaron Warnock, James J. Campbell, Martin E. Dorf, Akio Matsuzawa et autres

Chemokines have been hypothesized to contribute to the selectivity of lymphocyte trafficking not only as chemoattractants, but also by triggering integrin-dependent sticking (arrest) of circulating lymphocytes at venular sites of extravasation. We show that T cells roll on most Peyer's patch high …

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The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vitro- and in vivo-derived dendritic cells.

Sirid‐Aimée Kellermann, Susan A. Hudak, Elizabeth R. Oldham, Yong-Jun Liu et autres

Dendritic cell migration to secondary lymphoid tissues is critical for Ag presentation to T cells necessary to elicit an immune response. Despite the importance of dendritic cell trafficking in immunity, at present little is understood about the mechanisms that underlie this phenomenon. …

Specialization of mucosal follicular dendritic cells revealed by mucosal addressin-cell adhesion molecule-1 display

Margit C. Szabo, Eugene C. Butcher, L M McEvoy

Follicular dendritic cells (FDC) in the mucosal lymphoid organs, Peyer's patches (PP), display mucosal vascular addressin-cell adhesion molecule-1 (MAdCAM-1). MAdCAM-1 decorates interlacing dendritic cells throughout PP follicles and is accentuated on FDC of the germinal center (GC) light zone and on "junctional" …

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The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1.

Peter Altevogt, Marcus Hubbe, Michael Ruppert, Jens G. Lohr et autres

The heterodimeric alpha 4 integrins alpha 4 beta 7 lymphocyte Peyer's patch adhesion molecule ([LPAM]-1) and alpha 4 beta 1 (very late antigen-4) are cell surface adhesion molecules involved in lymphocyte trafficking and lymphocyte-cell and matrix interactions. Known cellular ligands include vascular …

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Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.

Philip S. Tsao, L M McEvoy, H G Drexler, Eugene C. Butcher et autres

BACKGROUND: We have shown that chronic administration of the nitric oxide (NO) precursor L-arginine normalizes NO-dependent vasodilation and markedly inhibits atherogenesis in a hypercholesterolemic rabbit model. We hypothesized that this antiatherogenic effect is due to modulation of endothelial adhesiveness by endothelium-derived NO. …

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L-selectin-mediated lymphocyte rolling on MAdCAM-1

Ellen Lakey Berg, L M McEvoy, Cornelia Berlin, Robert F. Bargatze et autres

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Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

Ulrich H. von Andrian, JD Chambers, L M McEvoy, Robert F. Bargatze et autres

The lectin homing receptor LECAM-1 (LAM-1, Leu8) and the beta 2 integrins, particularly Mac-1 (CD11b/CD18), participate in leukocyte-endothelial cell interactions in inflammation. LECAM-1 is rapidly shed while Mac-1 expression is dramatically increased upon neutrophil activation, suggesting functionally distinct roles for these molecules. …

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