Aravindan Narayanan

SP 11.13 Extending “Resect and Discard” Beyond Screening: Feasibility for Small and Diminutive Colorectal Polyps in All-Comers

Sithdharthan Ravikumar, Shashikanth Vijayaraghavalu, Namrata Aravindan, Sanjana Susarla et autres

Abstract Aim Most colorectal polyps removed at colonoscopy are diminutive or small and rarely show advanced pathology. Routine histology for these low-risk lesions creates significant cost and workload with limited clinical benefit. This study evaluates outcomes for diminutive and small polyps in …

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TPW 1.11 Does Timing Matter? Time to Surgery from Diagnosis and its Effect on Outcomes in Acute Appendicitis

Olufemi Oduneye, Shashikanth Vijayaraghavalu, Sithdharthan Ravikumar, Aravindan Narayanan et autres

Abstract Aim Surgical intervention remains the definitive treatment for acute appendicitis and can be time critical. This study assesses whether delays in surgery contributed to increased rates of appendiceal perforation in adult patients and impacts on hospital stay. Methods Data were retrospectively …

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EP 182 A Rare Cause of Closed-Loop Obstruction: Caecal Volvulus within a Petersen’s Hernia following Gastric Bypass

Altaf Haji, Zain Khan, Stephen Stonelake, Aravindan Narayanan et autres

Abstract Keywords Caecal volvulus, Petersen’s hernia, Gastric bypass, Closed-loop obstruction, Internal hernia, Acute abdomen Background Internal herniation through Petersen’s defect is a recognised late complication of Roux-en-Y gastric bypass, usually involving small bowel loops. Caecal volvulus within a Petersen’s hernia is extremely …

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TPW 2.08 Post-Colonoscopy Colorectal Cancer (PCCRC): Two-Year Audit Using the WEO Framework to Target Preventable Harm

Zain Ahmed Khan, Shashikanth Vijayaraghavalu, Sithdharthan Ravikumar, Namrata Aravindan et autres

Abstract Aims Post-colonoscopy colorectal cancer (PCCRC) is a key quality marker reflecting missed lesions, incomplete therapy, or pathway delays. We audited PCCRC rates across two annual cohorts and applied the World Endoscopy Organization (WEO) framework to identify avoidable factors and improvement actions. …

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Reassessing drainage strategies for anastomotic leak after elective anterior resection: Insights from a systematic review and pooled analysis

Sithdharthan Ravikumar, Aravindan Narayanan

The author declares no conflicts of interest. No new datasets were generated or analysed for this commentary.

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Harnessing m6A-regulated cholesterol biosynthesis helps impede tumor burden and stemness in high-garde serous ovarian carcinoma mesenchymal phenotype

Aravindan Narayanan, Kiran Dhenge, Sharmila A. Bapat

Post-transcriptional RNA modifications have emerged as critical regulators of stemness, cellular plasticity, adaptation to stress and transformation. Amongst these the N6-methyladenosine (m6A) modification orchestrates a wide range of physiological processes; yet its contribution to metabolic regulation remains poorly addressed. In the present …

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Association Between the Prognostic Nutritional Index and Outcomes in Patients Undergoing Emergency Laparotomy

Sithdharthan Ravikumar, Kasun Wanigasooriya, Shashikanth Vijayaraghavalu, Lanoayo Agbabiaka et autres

Background: Nutritional status is a key determinant of surgical outcomes, but its assessment in emergency settings remains challenging. The prognostic nutritional index (PNI), which is derived from the serum ALB concentration and lymphocyte count, is a rapid, objective measure of nutritional and …

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Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells

Aravindan Narayanan, Souvik Guha, Avinash M. Mali, Sharmila A. Bapat

Ex vivo stem cell self-renewal and maintenance is supported by absence of serum-derived mitogens. In the present study, we sought to elucidate the proteomes of stem-like cells grown in serum-free media across a panel of high-grade serous ovarian cancer cell lines, which …

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A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background

Aravindan Narayanan, Ankita S. More, Muskan Talreja, Avinash M. Mali et autres

BACKGROUND: Transcript variants and protein isoforms are central to unique tissue functions and maintenance of homeostasis, in addition to being associated with aberrant states such as cancer, where their crosstalk with the mutated tumor suppressor p53 may contribute to genomic instability and …

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WP5.16 - Profile of Colorectal cancers presenting as emergencies at GEH during last 3 years - (Jan 2019 -Jan 2022) Incidence, presentations ,treatment options Biology, and prognosis -Single institutional experience

Altaf GAUHAR Haji, Shashikanth Vijayaraghavalu, Ali Ali Elhassan, Aftab Ahmad et autres

Abstract Aim This retrospective, single-institutional study aimed to comprehensively investigate the demographic features, clinical presentations, and outcomes of emergency procedures in individuals with colorectal cancers presenting as acute emergencies at GEH over the last three years. Methods In this study at GEH, …

Never reported complication of open right hemicolectomy-right external iliac artery pseudoaneurysm with arterio colonic fistulae presenting as delayed postoperative anastomotic bleeding: a case report and review of literature

Altaf GAUHAR Haji, Ali M. Elhassan, Aravindan Narayanan, Bala Piramanayagam et autres

Anastomotic bleeding is well known complication after gastrointestinal resection and anastomosis procedures. The percentage of patients experiencing this complication is between 0.5% to 9.6%. Delayed postoperative anastomotic bleeding is even more rare, herein, we report a case of pseudoaneurysm of right external …

Idiopathic spontaneous lesser sac haematoma: a perplexing case of abdominal apoplexy

Nikita Da Cunha, Aravindan Narayanan, Kalimuthu Marimuthu, Bala Piramanayagam

A 37-year-old woman presented with a 3-hour history of back pain, nausea and vomiting and an episode of syncope. A fluid collection in the lesser sac was detected on ultrasound and CT scan. Emergency laparoscopy and subsequent laparotomy were performed and a …

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