Sachio Takashima

Near‐infrared light scattering and water diffusion in newborn brains

Sachiko Iwata, Reiji Katayama, Kennosuke Tsuda, Yung‐Chieh Lin et autres

Abstract Objective MRI provides useful information regarding brain maturation and injury in newborn infants. However, MRI studies are generally restricted during acute phase, resulting in uncertainty around upstream clinical events responsible for subtle cerebral injuries. Time‐resolved near‐infrared spectroscopy non‐invasively provides the reduced …

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Foetal growth, birth transition, enteral nutrition and brain light scattering

Osuke Iwata, Sachiko Iwata, Tsuyoshi Kurata, Kennosuke Tsuda et autres

Abstract If the brain structure is assessed at neonatal intensive care units, covert clinical events related with subtle brain injury might be identified. The reduced scattering coefficient of near-infrared light (μS’) obtained using time-resolved near-infrared spectroscopy from the forehead of infants is …

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Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency

Mayumi Matsufuji, Eiko Takeshita, Masayuki Nakashima, Yoriko Watanabe et autres

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Prognostic Estimation of Perinatal Brain Damage on Early Cranial MRI Findings for Early Preventive Rehabilitation

Shunichi TASHIRO, Miwa Takashima, Sachiko Iwata, Masaharu MORITA et autres

〔目的〕周産期脳障害において早期MRIから脳障害特性評価と予後予測の可能性を調査する．〔対象と方法〕療育施設利用者のNICU退院時頭部MRIより在胎週数別に異常部位の視覚的評価と部位別の径計測，また白質異常部位と臨床所見と対比した．〔結果〕すべての群で大脳白質に異常所見が多く，白質部位別では在胎22～26週群では全体，27～32週群では中間部と脳室周囲，33～36週群では中間部，37～40週群では皮質下に異常が多くみられた．白質の皮質下異常では自閉スペクトラム症が有意に多く四肢麻痺と重度知的障害が多い傾向にあった．脳室周囲異常では軽度知的障害が有意に多く痙性両麻痺が多い傾向にあった．〔結語〕大脳白質異常は在胎週数別で特徴があり，予防的リハビリを実施することは重要である．

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Body Temperature, Heart Rate, and Short-Term Outcome of Cooled Infants

Kennosuke Tsuda, Sachiko Iwata, Takeo Mukai, Jun Shibasaki et autres

Therapeutic hypothermia following neonatal encephalopathy is neuroprotective. However, approximately one in two cooled infants still die or develop permanent neurological impairments. Further understanding of variables associated with the effectiveness of cooling is important to improve the therapeutic regimen. To identify clinical factors …

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Estimation of elevated intracranial pressure in infants with hydroce-phalus by using transcranial Doppler velocimetry with fontanel compression

Teiko Yoshizuka, Masahiro Kinoshita, Sachiko Iwata, Kennosuke Tsuda et autres

Abstract For infants with acute progressive hydrocephalus, invasive drainage of cerebrospinal fluid (CSF) is performed until a ventriculo-peritoneal shunt can be inserted. Surrogate markers of intracranial pressure (ICP) may help optimise the timing of invasive procedures. To assess whether RI with/without fontanel …

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Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Ken‐ichiro Kubo, Kimiko Deguchi, Taku Nagai, Yukiko Ito et autres

Many extremely preterm infants (born before 28 gestational weeks [GWs]) develop cognitive impairment in later life, although the underlying pathogenesis is not yet completely understood. Our examinations of the developing human neocortex confirmed that neuronal migration continues beyond 23 GWs, the gestational …

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Neuroimaging and neuropathological characteristics of cerebellar injury in extremely low birth weight infants

Mayumi Matsufuji, Nozomi Sano, Hisashi Tsuru, Sachio Takashima

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Evaluation of Cognitive Function When Hearing One's Own Name in Patients With Brain Injuries in Early Developmental Stages

Kaori Tamura, Takaaki Mizuba, Tsuyoshi Okamoto, Mayumi Matsufuji et autres

PURPOSE: The level of residual cognitive function in patients with early brain injury is a key factor limiting rehabilitation and the quality of life. Although understanding residual function is necessary for appropriate rehabilitation, the extent of its effects on cognitive improvement remains …

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Region-specific growth restriction of brain following preterm birth

Sachiko Iwata, Reiji Katayama, Masahiro Kinoshita, Mamoru Saikusa et autres

Abstract Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate …

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Physiological and pathological clinical conditions and light scattering in brain

Tsuyoshi Kurata, Sachiko Iwata, Kennosuke Tsuda, Masahiro Kinoshita et autres

MRI of preterm infants at term commonly reveals subtle brain lesions such as diffuse white matter injury, which are linked with later cognitive impairments. The timing and mechanism of such injury remains unclear. The reduced scattering coefficient of near-infrared light (μs') has …

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Development of Catecholaminergic Neurons and Substance P-Positive Nerve Fibers in the Brain Stem of Victims of Sudden Infant Death Syndrome

Sachio Takashima, Hideo Yamanouchi, Laurence E. Becker

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