Koji Matsumoto

Barriers and facilitators for online genetic care for hereditary cancer in Japan: findings from surveys of both clients and medical professionals

Sayaka Ueno, Yusaku Urakawa, Fumino Kato, Arisa Ueki et autres

BACKGROUND: Online genetic care can offer a promising solution to the shortage of qualified medical professionals in genetic medicine, which leads to regional disparities in access. However, despite global adoption, its use in Japan remains limited. METHODS: Two questionnaire surveys were conducted …

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Risk Factors for Suicide in Patients With Head and Neck Squamous Cell Carcinoma

Tatsuji Nishiguchi, Ichiro Tojima, Kai Yamazaki, Kento Kawakita et autres

Background Head and neck squamous cell carcinoma (HNSCC) is associated with a high risk of suicide, partly because of the functional morbidity caused by the disease and its treatment. This study aimed to identify risk factors for suicide among patients with HNSCC, …

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Clinical trial of safety and antitumor activity of farletuzumab ecteribulin in patients with platinum‐resistant ovarian cancer: Phase I expansion results

Kan Yonemori, Mayu Yunokawa, Koji Matsumoto, Kazuhiro TAKEHARA et autres

OBJECTIVE: In the dose-escalation part of Study 101, which included multiple tumor types, objective responses were observed in 10 of 22 patients across multiple dose levels of farletuzumab ecteribulin (FZEC). We explored the safety/antitumor activity of FZEC in patients with platinum-resistant ovarian …

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Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Cutaneous Squamous Cell Carcinoma 2025

Toshihiro Takai, Takafumi Kadono, Noriki Fujimoto, Eisaku Yoden et autres

This revision work was commissioned by the Japanese Dermatological Association (JDA) and was undertaken by a committee of experts in related fields. The committee prepared comprehensive, evidence-based guidelines by thoroughly reviewing and systematizing a wide range of literature on cutaneous squamous cell …

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Study of PEEK composite for sliding mechanisms in space environment

Koji Matsumoto, Keiichi Yanagase, Satoshi Takada

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First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial

Christian Marth, Richard G. Moore, Mariusz Bidziński, Sandro Pignata et autres

PURPOSE Lenvatinib plus pembrolizumab (len + pembro) significantly improved progression-free survival (PFS) and overall survival (OS) versus chemotherapy in previously treated advanced or recurrent endometrial cancer (aEC) in the phase III Study 309/KEYNOTE-775. We report results from the phase III, randomized, open-label …

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First-line pembrolizumab with or without chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up of the Japanese population of KEYNOTE‑048

Nobuhiko Oridate, Shunji Takahashi, Kaoru Tanaka, Yasushi Shimizu et autres

BACKGROUND: Previously reported results from phase III KEYNOTE-048 demonstrated similar or improved overall survival (OS) with pembrolizumab or pembrolizumab-chemotherapy versus cetuximab-chemotherapy (EXTREME) in Japanese patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). We report results in Japanese patients from …

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Role of basal cells in nasal polyp epithelium in the pathophysiology of eosinophilic chronic rhinosinusitis (eCRS)

Kento Kawakita, Hideaki Kouzaki, Takuya Murao, Yoshihito Kubo et autres

BACKGROUND: Basal cell hyperplasia is commonly observed in nasal polyp epithelium of eosinophilic chronic rhinosinusitis (eCRS). We examined the function and mechanisms of basal cell hyperplasia in the pathophysiology of eCRS. METHODS: We found that normal human bronchial epithelial (NHBE) cells obtained …

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Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial

Jean‐Pascal Machiels, Yungan Tao, Lisa Licitra, Barbara Burtness et autres

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Surgical Outcomes in Patients with Middle Ear Malformations: A Retrospective Study of 23 Cases

Takuya Murao, Koji Matsumoto, Takeshi Shimizu

Introduction: This retrospective study was aimed at evaluating the surgical outcomes of 23 ears of patients with middle ear malformations who had undergone primary surgery at the Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science hospital, between December 2004 …

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Surgical Outcomes in Patients with Otosclerosis: A Retrospective Study of 31 Ears

Takuya Murao, Koji Matsumoto, Takeshi Shimizu

Introduction: This retrospective study was aimed at evaluating the surgical outcomes of 31 ears of patients with otosclerosis who had undergone primary stapedial surgery at the Department of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science hospital, between October 2004 and …

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Surgical Outcomes in Adult Patients with Acquired Cholesteatoma

Koji Matsumoto, Kento Kawakita, Takeshi Shimizu

We retrospectively reviewed the data of 190 adults (206 ears) with acquired cholesteatoma who had undergone tympanoplasty at our department between July 2010 and December 2021. The cholesteatoma stages, surgical strategies adopted, recurrence rate, and hearing improvement success rate were analyzed. The …

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