Ranajit Chakraborty

Supplemental Table 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Supplemental Table 1: Baseline Liver Characteristics by Dose Cohort, N = 13 Participants

Data from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Abstract Accumulation of the DNA adduct γ-hydroxy-1,N2-propanodeoxyguanosine (γ-OHPdG) is associated with hepatocellular carcinoma development. Theaphenon E—a green tea polyphenol extract dosed according to mg of epigallocatechin gallate—suppresses the formation of γ-OHPdG and reduces hepatocellular carcinoma development in preclinical models. This study aimed …

Supplemental Methods 1 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Supplemental Methods 1: Clinical Trial Protocol

Supplemental Table 2 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Supplemental Table 2: Adverse Events, N = 13 Participants

Supplemental Table 3 from A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Supplemental Table 3: Study Participants Representativeness Table

A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver γ-OHPdG Levels

Aiwu Ruth He, Coleman I. Smith, Marcia Cruz‐Correa, Ranajit Chakraborty et autres

Accumulation of the DNA adduct γ-hydroxy-1,N2-propanodeoxyguanosine (γ-OHPdG) is associated with hepatocellular carcinoma development. Theaphenon E-a green tea polyphenol extract dosed according to mg of epigallocatechin gallate-suppresses the formation of γ-OHPdG and reduces hepatocellular carcinoma development in preclinical models. This study aimed to …

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Challenges and Solutions in Design and Fabrication of Finger Prosthesis

Ranajit Chakraborty, Soumyo Chakroborty, Buddhadev Das, Chandan Chattoraj

The finger is important for its function and appearance. Finger loss causes functional and mental health issues. Finger prostheses are frequently not very long-lasting. It must be changed on a regular basis because frequent insertion and removal could cause permanent damage or …

Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry

Gita A. Pathak, Renato Polimanti, Talisa Silzer, Frank R. Wendt et autres

BACKGROUND: Proctitis is an inflammation of the rectum and may be induced by radiation treatment for cancer. The genetic heritability of developing radiotoxicity and prior role of genetic variants as being associated with side-effects of radiotherapy necessitates further investigation for underlying molecular …

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Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry

Gita A. Pathak, Renato Polimanti, Talisa Silzer, Frank R. Wendt et autres

Abstract BACKGROUND: Proctitis is an inflammation of the rectum and may be induced by radiation treatment for cancer. The genetic heritability of developing radiotoxicity and prior role of genetic variants as being associated with side-effects of radiotherapy necessitates further investigation for underlying …

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Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry

Gita A. Pathak, Renato Polimanti, Talisa Silzer, Frank R. Wendt et autres

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Differentiation of Hispanic biogeographic ancestry with 80 ancestry informative markers

Casandra Hernandez, John V. Planz, Robert C. Barber, Nicole Phillips et autres

Ancestry informative single nucleotide polymorphisms (SNPs) can identify biogeographic ancestry (BGA); however, population substructure and relatively recent admixture can make differentiation difficult in heterogeneous Hispanic populations. Utilizing unrelated individuals from the Genomic Origins and Admixture in Latinos dataset (GOAL, n = 160), …

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Transcriptomics & copy number variation of radiotoxicity points to altered mitochondrial and DNA repair mechanisms

Gita A. Pathak, Renato Polimanti, Talisa Silzer, Frank R. Wendt et autres

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