Philipp Czermak

Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics

Adriana Badarau, Benedikt Bauer, Zehra Visram, Renping Qiao et autres

Abstract Bacterial lysins are promising novel antimicrobials but are limited by poor pharmacokinetics and challenging manufacturability. We developed a lysin discovery platform tailored for lysin delivery via mRNA: staphylococcal LysM-CHAP (cysteine, histidine-dependent amidohydrolases/peptidase) autolysin was selected and its serum half-life extended via …

at, us, fr (code pays fourni par la source)

Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading

Stela Jelenić, Mathias S. Renaud, Samantha Del Borrello, Joseph Gokcezade et autres

Germ granules are liquid-like condensates that regulate small RNA pathways and gene expression, ensuring genome stability and fertility in animals. In C. elegans, several Argonaute proteins, central players of small RNA pathways, localize to germ granules, yet the functional significance of this …

at, ca (code pays fourni par la source)

Composition can buffer protein dynamics within liquid-like condensates

Stela Jelenić, János Bindics, Philipp Czermak, Balashankar R. Pillai et autres

at, de, us (code pays fourni par la source)

Author Reply to Peer Reviews of Composition can buffer protein dynamics within liquid-like condensates.

Stela Jelenić, János Bindics, Philipp Czermak, Balashankar R Pillai et autres

at, de, us (code pays fourni par la source)

Composition can buffer protein dynamics within liquid-like condensates

Stela Jelenić, János Bindics, Philipp Czermak, Balashankar R Pillai et autres

Summary Most non-membrane-bound compartments in cells that form via phase separation have complex composition. While phase separation of individual proteins that form these compartments is well-documented, the mechanisms that modulate dynamics of individual proteins in multicomponent systems remain unclear. Here, we used …

at, de, us (code pays fourni par la source)

Structural and Molecular Determinants of Dynamics in P Granules of C. Elegans

Stela Jelenić, János Bindics, Alex S. Holehouse, Martine Ruer et autres

at, us, de (code pays fourni par la source)

Organ-wide profiling in mouse reveals high editing levels of Filamin B mRNA in the musculoskeletal system

Philipp Czermak, Fabian Amman, Michael F. Jantsch, Laura Cimatti

Adenosine to inosine RNA editing in protein-coding messenger RNAs (mRNAs) potentially leads to changes in the amino acid composition of the encoded proteins. The mRNAs encoding the ubiquitously expressed actin-crosslinking proteins Filamin A and Filamin B undergo RNA editing leading to a …

at (code pays fourni par la source)

Organ-wide profiling in mouse reveals high editing levels of Filamin B mRNA in the musculoskeletal system

Philipp Czermak, Fabian Amman, Michael F. Jantsch, Laura Cimatti

Adenosine to inosine RNA editing in protein-coding messenger RNAs (mRNAs) potentially leads to changes in the amino acid composition of the encoded proteins. The mRNAs encoding the ubiquitously expressed actin-crosslinking proteins Filamin A and Filamin B undergo RNA editing leading to a …