Chenyu Zhang

Supplementary Figure 6 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

IT Treg ablation enhances tumor antigen acquisition by cDC2s.

Supplementary Figure 3 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Intratumoral Treg depletion promotes CD8+ and CD4+ T cell activation locally in tumors.

Supplementary Figure 5 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Ablation of IT Tregs in a single tumor unleashes antitumor immunity against distal tumors.

Supplementary Figure 4 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Conventional CD4+ T cells alone control tumors after IT Treg ablation.

Supplementary Figure 7 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

IT Treg ablation enhances tumor antigen cross presentation by cDC2s.

Data from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Abstract Regulatory T cells (Treg) infiltrate most tumors, and increased Treg infiltration is correlated with reduced survival in patients with cancer. Although Tregs suppress antitumor immunity, they are also integral for preventing harmful inflammation in nontumor tissues, hindering the development of cancer …

Supplementary Figure 1 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Intratumoral Treg depletion is sufficient to control tumor growth.

Supplementary Figure 2 from Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

IT Treg ablation without toxicity.

Immunotherapeutic control of MHC I-heterogeneous tumors to minimize therapy resistance 2307892

Abigail Mende, Sooyun Cho, Chenyu Zhang, Michel DuPage et autres

Abstract Introduction The anti-tumor activity of CD8 T cells, which recognize MHC I-presented tumor antigens, is enhanced by blocking checkpoint receptors. Longitudinal tumor biopsies from patients with acquired resistance to anti-PD-1 therapy often reveal genetic deficiencies in antigen presentation or MHC I …

us (code pays fourni par la source)

Single-cell viral capture identifies injury-remodeling programs and host-response candidates in RSV-infected airway organoids

R G Liu, Liu Zj, Pengbo Wang, Yi Zhang et autres

cn (code pays fourni par la source)

ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity

Yeara Jo, Alexandros Karampatzakis, Seung Won Lee, Alice Peng et autres

Summary Natural Killer (NK) cell desensitization induced by persistent stimulation limits durable antitumor immunity, yet the molecular mechanisms governing this dysfunctional state remain poorly defined. To identify conserved regulators of NK cell desensitization, we performed comparative transcriptomic analyses across multiple murine models …

us, gb (code pays fourni par la source)

Intratumoral Regulatory T-cell Ablation Mediates Tumor Control Systemically without Autoimmunity

Alissa Bockman, Chenyu Zhang, Brenna Gittins, Jessica Hung et autres

Regulatory T cells (Treg) infiltrate most tumors, and increased Treg infiltration is correlated with reduced survival in patients with cancer. Although Tregs suppress antitumor immunity, they are also integral for preventing harmful inflammation in nontumor tissues, hindering the development of cancer therapeutic …

us (code pays fourni par la source)