Siyuan Wan

Virtual Reality versus Screen-Based 3D Anatomy Applications for Teaching Lower Gastrointestinal Anatomy: A Pilot Randomized Controlled Trial (Preprint)

Florence Chang, Jason Ha, Siyuan Wan, Ameen R. Mahmood et autres

BACKGROUND Undergraduate anatomy teaching has faced sustained pressure from reduced curricular time, diminished access to cadaveric dissection, and variable teaching quality. The lower gastrointestinal tract (GI), with its complex three-dimensional (3D) relationships between the small and large bowel, mesentery, and vasculature, is …

Hearts, Minds, and Headlines: How the UK Junior Doctor Strikes Are Being Framed

Siyuan Wan

Industrial action by NHS resident doctors have repeatedly generated intense political and media scrutiny, with public discourse frequently centred on disruption, professional responsibility, and patient harm. The November 2025 strikes in England provided an opportunity to examine how public narratives surrounding these …

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Regulatory T cells and Beyond: Shimon Sakaguchi’s 2025 Nobel Prize in Physiology or Medicine

Siyuan Wan

The 2025 Nobel Prize in Physiology or Medicine, awarded to Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell, marks a defining milestone in modern immunology and the culmination of decades of inquiry into the mechanisms of immune tolerance. Sakaguchi has led a distinguished …

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Topology optimization of thermal-fluid problem using the anisotropic material field series expansion approach

Siyuan Wan, Hong Liu, Shengli Xu, Bo Wang

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Topology optimization for subsonic compressible flows based on the material field series expansion model

Siyuan Wan, Huiying Zhang, Mindi Jiang, Shengli Xu et autres

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Traditional Chinese medicine in the management of diabetic foot ulcers: an overview of meta-analyses

Xiaoman Liu, Siyuan Wan

Background: The global rise in diabetic foot ulcer (DFU) complications necessitates more effective therapeutic strategies. Traditional Chinese Medicine (TCM) has been increasingly explored as a potential adjunctive therapy for DFU management. This umbrella review synthesizes evidence from meta-analyses to evaluate the effectiveness …

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Exploring Factors Influencing the Consumption of Grape Skins: A Review

Siyuan Wan, Youmei Li, Zhaosen Xie

Grapes (Vitis vinifera L.) are one of the most popular fruits globally, with studies demonstrating the numerous beneficial metabolic substances found in their skins, including anthocyanins, proanthocyanidins, stilbene (resveratrol) and so on. However, grape skins are often overlooked and discarded by consumers. …

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Arsenic-induced hepatotoxicity: Mechanistic insights into TNFAIP3-mediated regulation of the NF-κB p65/IAPs Signaling Pathway

Baiming Jin, Haonan Li, Hua Zhang, Lele Liu et autres

Exposure to excessive arsenic results in progressive liver injury, although the underlying mechanisms are not yet fully elucidated. This study aims to investigate whether TNFAIP3 plays a protective role within the transcriptional regulatory network linking with NF-κB p65 and IAPs. A model …

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DNA methylation of genes that mediate autophagosome formation contributes to iodine-induced autoimmune thyroiditis: A population-based study conducted at regions with different iodine levels in China

Bingxuan Ren, Yun Chen, Jinjin Liu, Zheng Zhou et autres

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Effect of decitabine on PD-L2 methylation in whole blood of iodine-induced autoimmune thyroiditis rats

Baiming Jin, Yanbo Qi, Chao Hong, Xiaolei Yang et autres

Excessive iodine intake can induce autoimmune thyroiditis (AIT), and the methylation of programmed death receptor 2 ( PD-L2 ) may be involved in the development of iodine-induced AIT. Here, we investigated the immune role of methylation of the susceptibility gene PD-L2 in …

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Polypharmacological Drug Design Guided by Integrating Phenotypic and Restricted Fragment Docking Strategies

Shang Li, Xinxin Li, Liangliang Ma, Zhongwen Luo et autres

Polypharmacological drugs are of great value for treating complex human diseases by the combinative modulation of several biological targets. However, multitarget drug design with more than two targets is challenging and generally discovered by serendipity. Herein, a restricted fragment docking (RFD) computational …

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Differential regulation of xylem and phloem differentiation in grape berries by GA3 and CPPU

Youmei Li, Xuan-Si Tang, Weiqing Feng, Siyuan Wan et autres

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