Mario Sims

Cumulative exposure to risk factors and subsequent cardiovascular disease events: The Jackson Heart Study

Rishi Parikh, Paul De Munter, Shakia T. Hardy, Mario Sims et autres

Abstract Background Cumulative exposure to risk factor levels may capture cardiovascular disease (CVD) risk independent of a single measurement. We examined the association between cumulative exposure to systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) with CVD …

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Neighborhood built environment and leukocyte telomere length among African American adults in the Jackson Heart Study

Mohammad Moniruzzaman, Yangyang Deng, Lauren A. Reid, Allana T. Forde et autres

Abstract Background Evidence on the relationship between the built environment and leukocyte telomere length (LTL), a biomarker of cellular aging, is limited and inconsistent, with intermediary factors and the moderating role of sex remaining understudied. Purpose This study examined the direct associations …

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Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study

Amber J. Johnson, Mario Sims, Chelsea Okundolor, Sherman A. James et autres

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Multilevel Mediators on the Associations of Neighborhood Social Environmental Factors and Severity of Metabolic Syndrome: The Jackson Heart Study

Mohammad Moniruzzaman, Lauren A. Reid, Kelly K. Jones, Shannon N. Zenk et autres

BACKGROUND: Neighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex-specific mediating role of C-reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood …

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DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults

LáShauntá M. Glover, Adam G. Lilly, Anne E. Justice, Annie Green Howard et autres

Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic mechanisms mediate the effect of socioeconomic status (SES) on BMI. Using data …

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Karen Schwander et autres

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride …

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