Cathy L. Budman

Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders

Marisela Dy-Hollins, Lori B. Chibnik, Natasha Tracy, Lisa Osiecki et autres

OBJECTIVES: To analyze sex differences in outcomes in Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) in the Tourette Association of America International Consortium for Genetics (TAAICG) dataset. METHODS: The relationship between sex and clinical measures was explored in …

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Diagnosis and management of functional tic-like phenomena

Irene A. C. Malaty, Seonaid Anderson, Shannon M. Bennett, Cathy L. Budman et autres

Over the past 3 years, a global phenomenon has emerged characterized by the sudden onset and frequently rapid escalation of tics and tic-like movements and phonations. These symptoms have occurred not only in youth known to have tics or Tourette syndrome (TS), …

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Synaptic processes and immune-related pathways implicated in Tourette Syndrome

Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang et autres

Abstract Tourette Syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with …

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil H. Lee, Verneri Anttila, Hyejung Won, Yen‐Chen Anne Feng et autres

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Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

Dongmei Yu, Jae Hoon Sul, Fotis Tsetsos, Muhammad Sulaman Nawaz et autres

OBJECTIVE: Tourette's syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette's syndrome and other tic disorders. The authors conducted a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk …

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Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome

Erica Greenberg, Esther S. Tung, Caitlin Gauvin, Lisa Osiecki et autres

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Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome

Matthew E. Hirschtritt, Sabrina M. Darrow, Cornelia Illmann, Lisa Osiecki et autres

BACKGROUND: The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families. METHOD: OCD and ADHD …

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Autism Spectrum Symptoms in a Tourette’s Disorder Sample

Sabrina M. Darrow, Marco A. Grados, Paul Sandor, Matthew E. Hirschtritt et autres

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896. Genetic and Phenotypic Overlap of Specific Obsessive-Compulsive Subtypes with Tourette Syndrome

Matthew E. Hirschtritt, Sabrina M. Darrow, Cornelia Illmann, Lisa Osiecki et autres

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Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome

Sabrina M. Darrow, Matthew E. Hirschtritt, Lea K. Davis, Cornelia Illmann et autres

OBJECTIVE: Phenotypic heterogeneity in Tourette syndrome is partly due to complex genetic relationships among Tourette syndrome, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). Identifying symptom-based endophenotypes across diagnoses may aid gene-finding efforts. METHOD: Assessments for Tourette syndrome, OCD, and ADHD …

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Social disinhibition is a heritable subphenotype of tics in Tourette syndrome

Matthew E. Hirschtritt, Sabrina M. Darrow, Cornelia Illmann, Lisa Osiecki et autres

OBJECTIVE: To identify heritable symptom-based subtypes of Tourette syndrome (TS). METHODS: Forty-nine motor and phonic tics were examined in 3,494 individuals (1,191 TS probands and 2,303 first-degree relatives). Item-level exploratory factor and latent class analyses (LCA) were used to identify tic-based subtypes. …

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Genetic association signal near NTN 4 in T ourette syndrome

Peristera Paschou, Dongmei Yu, Gloria F. Gerber, Patrick Evans et autres

Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. …

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