Gabriele Nicolini

Efficacy of citicoline as an add-on therapy in Parkinson's disease: a randomized, double-blind trial

Massimo Marano, Andrea Pilotto, Giancarlo Logroscino, Alessandro Stefani et autres

BACKGROUND: Citicoline is a promising therapeutic option for improving both motor and non-motor symptoms in Parkinson's disease (PD) beyond levodopa and other standard dopaminergic treatments. OBJECTIVES: The CITIPARK study evaluated the efficacy and safety of citicoline in improving clinical outcomes and quality …

it (code pays fourni par la source)

Pharyngeal Microbiota in Pre-COPD and COPD: Associations with Clinical Pattern and Respiratory Infection

Melissa Ferraris, Chiara Pollicardo, Nicole Colombo, Ludovica Napoli et autres

Background/Objectives: The pharyngeal microbiota plays a critical role in respiratory health by supporting immune modulation, colonization resistance, and metabolic functions. Disruptions in this microbial ecosystem are associated with respiratory diseases; however, standard diagnostics often target individual pathogens, overlooking overall microbial dynamics. This …

it (code pays fourni par la source)

Sublingually administered bacterial lysates: rationale, mechanisms of action and clinical outcomes

Fulvio Braido, Giovanni Melioli, Gabriele Nicolini, Melissa Ferraris et autres

This review discusses available evidence on the mechanisms of action of bacterial lysates, and the clinical effects of their sublingual administration. Bacterial lysates act through many immunological effects, including dendritic cell activation, modification of circulating lymphocyte subsets and antibody production. The production …

it (code pays fourni par la source)

A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

Flavia Lucia Lombardo, Stefania Spila Alegiani, Flávia Mayer, Marta Cipriani et autres

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements in therapeutic options for ALS patients in recent years. Currently, there is no cure for …

it, am, de, gb, fr, be, nl, ie (code pays fourni par la source)

A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

Flavia Lucia Lombardo, Stefania Spila Alegiani, Flávia Mayer, Marta Cipriani et autres

it, de, gb, fr, be, nl, ie (code pays fourni par la source)

Prevention of recurrent respiratory tract infections: a literature review of the activity of the bacterial lysate Lantigen B.

Fulvio Braido, Giovanni Melioli, Gabriele Nicolini, Giorgio Walter Canonica

OBJECTIVE: Lantigen B, a bacterial lysate, was developed in the 1960s and showed a prophylactic effect in patients with recurrent respiratory tract infections. The objective of this article is to review the literature to update the efficacy and safety profile of Lantigen …

it (code pays fourni par la source)

Development of a tool to detect small airways dysfunction in asthma clinical practice

Janwillem W.H. Kocks, Thys van der Molen, Jaco Voorham, Simonetta Baldi et autres

BACKGROUND: Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool including items of the Small Airways Dysfunction Tool (SADT) questionnaire, basic patient characteristics and …

nl, sg, gb, it, us, de (code pays fourni par la source)

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study

Tessa Kole, Edward Vanden Berghe, Monica Kraft, Judith M. Vonk et autres

Background Persistent airflow limitation (PAL) occurs in a subset of patients with asthma. Previous studies on PAL in asthma have included relatively small populations, mostly restricted to severe asthma, or have no included longitudinal data. The aim of this post-hoc analysis was …

nl, be, us, gb, it, de, se, es (code pays fourni par la source)

Prolonged-Release Once-Daily Formulation of Tacrolimus Versus Standard-of-Care Tacrolimus in de novo Kidney Transplant Patients Across Europe

Klemens Budde, Lionel P. E. Rostaing, Umberto Maggiore, Giovanni Piotti et autres

Background: Tacrolimus is the calcineurin inhibitor of choice for preventing acute rejection episodes in kidney transplant patients. However, tacrolimus has a narrow therapeutic range that requires regular monitoring of blood concentrations to minimize toxicity. A new once-daily tacrolimus formulation, LCP-tacrolimus (LCPT), has …

de, fr, it, es, be, at, pl, no, se (code pays fourni par la source)

The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study

Monica Kraft, Matthew W. Richardson, Brian Hallmark, Dean D. Billheimer et autres

us, gb, nl, it, de (code pays fourni par la source)

Small Airways: Not Just Air Ducts – Pathophysiological Aspects and Clinical Implications

Annalisa Frizzelli, Gabriele Nicolini, Alfredo Antonio Chetta

The airways smaller than 2 mm diameter are named small airways. They are essential for the transport and exchange of oxygen and carbon dioxide and at the same time play a relevant role in pulmonary mechanics, contributing to the subdivision of lung …

it (code pays fourni par la source)

Kleine Atemwege: Nicht nur Luftkanäle – pathophysiologische Aspekte und klinische Implikationen

Annalisa Frizzelli, Gabriele Nicolini, Alfredo Antonio Chetta

Atemwege mit einem Durchmesser von weniger als 2 mm werden als kleine Atemwege bezeichnet. Sie sind essenziell für den Transport und Austausch von Sauerstoff und Kohlendioxid und spielen gleichzeitig eine wichtige Rolle in der Lungenmechanik und tragen zur Unterteilung des Lungenvolumens bei. …

it, fr (code pays fourni par la source)