Michael T. Aboujaoude

CLO26-076: Prognostic Outcomes in Resected Pancreatic Cancer Treated With Neoadjuvant Chemotherapy Alone: Impact of Integrated Pathologic Score

Jin-Ju Lee, Michael T. Aboujaoude, Adrianna Oraiqat, Tyler Horiuchi et autres

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Melanoma brain metastases outcomes following nivolumab and relatlimab after ipilimumab and nivolumab progression

Vaseem Khatri, Michael T. Aboujaoude, Lilit Karapetyan, Ahmad A. Tarhini et autres

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Prognostic Impact of Recreational Drug Use on 1-Year Outcomes in NSTEMI and STEMI Patients

Michael T. Aboujaoude, Nefissa Hamache, Jean Guillaume Dillinger, Antonin Trimaille et autres

BACKGROUND: Recreational drug use is increasingly associated with adverse outcomes in acute coronary syndrome (ACS) patients, but differences in long-term outcomes between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction are not well defined. OBJECTIVES: The authors evaluated the association …

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T-cell receptor anti-CMV CDR3s from bone marrow samples are associated with a worse overall survival for recurrent acute myeloid leukemia

Srijit Paul, Michael T. Aboujaoude, Vayda R. Barker, Tabitha R. Hudock et autres

We assessed the relationship of AML patient outcomes and T-cell receptor (TCR) recombination reads representing known anti-viral TCR sequences. TCR complementary determining region-3's (CDR3s) were obtained from the pediatric TARGET-AML dataset, and the TCR CDR3s representing bone marrow samples of primary and …

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Real-World Use of Nivolumab plus Relatlimab in the Multi-Modal Management of Melanoma Brain Metastases

Vaseem Khatri, Michael T. Aboujaoude, John Michael Bryant, J.Y. Nakashima et autres

Detection of Anti‐ CMV TCR CDR3s via Blood and Tumor Exome Files Correlates With Increased Survival for Stomach Adenocarcinoma and Soft Tissue Sarcoma

Upender Kapoor, Michael T. Aboujaoude, Konrad J. Cios, Andrea Chobrutskiy et autres

While the role of anti-cytomegalovirus (CMV) T-cell responses in the cancer setting is becoming increasingly recognized, the association between CMV and survival outcomes has not been subject to study through more recent immunogenomic approaches. Thus for this study, we extracted T-cell receptor …

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Benchmarking clinical reasoning and accuracy of large language models on breast oncology multiple-choice questions.

Roupen Odabashian, Ameer Basta, Ritu Sidgal, Trevor Lin et autres

e13637 Background: Large language models (LLMs) like GPT-4 (OpenAI) and Claude Opus (Anthropic) showed high accuracy in medical multiple-choice exams, but data on their oncology-specific clinical reasoning and performance is limited. This study evaluates their accuracy and clinical reasoning on breast oncology …

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Abstract 6254: Detection of anti-CMV TCR CDR3s correlates with increased survival for soft tissue sarcoma and stomach adenocarcinoma

Michael T. Aboujaoude, Konrad J. Cios, Andrea Chobrutskiy, Boris I. Chobrutskiy et autres

Abstract Introduction: While the role of anti-cytomegalovirus (CMV) T-cell responses in the cancer setting is becoming increasingly recognized, the association between CMV and survival outcomes has not been subject to study through more recent immunogenomic approaches. This study aimed to investigate the …

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Better Outcomes for Ovarian Cancer Associated With the Detection of Anti‐EBV TCR CDR3s: Potential Relevance to Diffuse Large B‐Cell Lymphoma

Nandini Goel, Madeline C. Baker, Michael T. Aboujaoude, Michael J. Diaz et autres

OBJECTIVES: Given the ongoing challenges regarding the specific roles of viral infections in cancer etiology, or as cancer co-morbidities, this study assessed potential associations between anti-viral, T-cell receptor (TCR) complementarity domain region-3 (CDR3s), and clinical outcomes for ovarian cancer. METHODS: TCR CDR3s …

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High GLP1R gene copy numbers associated with microsatellite instability for multiple cancers and with better survival probabilities for glioblastoma

Michael T. Aboujaoude, Vayda R. Barker, Mallika Varkhedi, Rahul Jain et autres

While the Warburg effect is well-known and frequently studied, the molecular features that facilitate increased tumor cell glycolytic activity have yet to be extensively investigated. We hypothesized that amplification of genes encoding proteins related to glucose metabolism could be a mechanism to …

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Chemical Complementarity of Blood-Sourced, Breast Cancer-Related TCR CDR3s and the CMV UL29 and IE1 Antigens is Associated with Worse Overall Survival

Pooja Neerumalla, Rahul Jain, Michael T. Aboujaoude, Tabitha R. Hudock et autres

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