Johanna Gentz

Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer’s disease model

Juan Zu, Cong Li, Mochen Cui, Xinwu Liu et autres

Synaptic loss is an early hallmark of Alzheimer's disease (AD), predominantly driven by aberrant microglial reactivity. Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with anti-diabetic properties, has been shown to suppress microglial activity and improve cognitive performance in both AD models …

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Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease

Carolin Meyer, Theresa Niedermeier, Paul Feyen, Felix L. Struebing et autres

Abstract Alzheimer’s disease (AD) often begins with non-cognitive symptoms such as olfactory deficits, which can predict later cognitive decline, though the mechanisms remain unclear. Pathologically, the brainstem locus coeruleus (LC), the main source of the neurotransmitter noradrenalin (NA) modulating olfactory information processing …

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Noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease

Carolin Meyer, Theresa Niedermeier, Paul Feyen, Felix Strübing et autres

de, au (code pays fourni par la source)