Accès ouvert
2026
article
OpenAlex
Uroš Markovic, Gabriele Sapuppo, Sara Frazzetto, Stephanie Grasso et autres
Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder caused by severe ADAMTS13 deficiency, leading to microvascular platelet-rich thrombi, hemolysis, and organ damage, mainly involving brain, heart, kidneys, and intestines. Standard treatment includes plasma exchange (PEX) and immunosuppressants. Caplacizumab (CAPLA), …
it, ru
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Accès ouvert
2026
article
OpenAlex
Vittorio Del Fabro, Lara Gullo, Giuliana Giunta, Giuseppina Uccello et autres
BACKGROUND: Multiple myeloma (MM) is a clonal plasma cell neoplasm representing the second most common hematological malignancy. The combination of daratumumab, lenalidomide and dexamethasone (D-Rd) was first approved by the EMA (European Medicines Agency) for the treatment of relapsed/refractory multiple myeloma (RRMM) …
it
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Accès ouvert
2025
article
OpenAlex
Gaetano Giuffrida, Uroš Markovic, Stephanie Grasso, Andrea Duminuco et autres
BACKGROUND: Acquired haemophilia A (AHA) is a rare and severe bleeding disorder generally associated with pregnancy or aging. Spontaneous remission and prompt inhibitor eradication are described more frequently in postpartum cases. We evaluated retrospectively 15 postpartum AHA cases between 2007 and 2023 …
it
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2024
conference-abstract
OpenAlex
Uroš Markovic, Sara Frazzetto, Stephanie Grasso, Giuliana Giunta et autres
Introduction. Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disease caused by a severe deficiency of the metalloproteinase ADAMTS13, that results in platelet-rich thrombi in the microvessels, with subsequent red cells fragmentation and end-organ damage, predominantly affecting the brain, heart, kidneys …
it
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Accès ouvert
2024
article
OpenAlex
Manlio Fazio, Chiara Maria Catena Sorbello, Vittorio Del Fabro, Alessandra Romano et autres
Neoplastic plasma cells (PCs) proliferation at anatomic sites dislocated from the bone marrow (BM) or their contiguous growth from osseous lesions that disrupt the cortical bone is termed extramedullary multiple myeloma (EMD). EMD still remains challenging from a therapeutic and biological perspective. …
it
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