Frida Anguiano

How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate

Valeria Jaramillo‐Martinez, Ritika Kukreja, Maurice Cohen, Ally F. Mujica et autres

Electrostatic interactions often play a role in determining the thermodynamic and kinetic properties of protein-protein interactions. However, the role of long-range electrostatic interactions in intrinsically disordered protein (IDP) binding is less clear, as they often bind in multiple steps including initial formation …

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Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice

Ken Matoba, Eisuke Dohi, Phoebe A. Garcia, Jose Francis-Oliveira et autres

Abstract Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired …

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Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in mice

Ken Matoba, Eisuke Dohi, Phoebe A. Garcia, José Fernando de Oliveira et autres

Abstract Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired …

us, jp (code pays fourni par la source)

SH3 binding pathway and kinetics in the presence of salt

Frida Anguiano, Oluebube Onwuzulu, Anna Carhart, Elliott J. Stollar et autres

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