Rachel Whichelo

Suzetrigine for Acute Pain and Its Potential Relevance to Postoperative Pain Following Third-Molar Extraction: A Scoping Review

Arya Emami, Rachel Whichelo, Hassan El-Awour

This project is a scoping review examining the extent and nature of human clinical evidence for suzetrigine (Journavx; VX-548), a selective NaV1.8 sodium-channel inhibitor approved by the FDA in January 2025 for moderate-to-severe acute pain, with a focus on its relevance to …

Progress in Precision Medicine for Head and Neck Cancer

Sanaz Vakili, Amir Barzegar Behrooz, Rachel Whichelo, Alexandra Ramos Fernandes et autres

This paper presents a comprehensive comparative analysis of biomarkers for head and neck cancer (HNC), a prevalent but molecularly diverse malignancy. We detail the roles of key proteins and genes in tumourigenesis and progression, emphasizing their diagnostic, prognostic, and therapeutic relevance. Our …

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Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches

Sahar Mafi, Mehdi Dehghani, Bahman Khalvati, Hassan Abidi et autres

Colorectal cancer (CRC) ranks among the leading causes of cancer-related deaths worldwide. Enhancing CRC diagnosis and prognosis requires the development of improved biomarkers and therapeutic targets. Emerging evidence suggests that the unfolded protein response (UPR) plays a pivotal role in CRC progression, …

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