Stephen E. Kimmel

Rate of nicotine metabolism on risk of myocardial infarction among people with HIV who smoke cigarettes

Derartu Ahmed, Warren B. Bilker, Xiaoyan Han, Rachel F. Tyndale et autres

BACKGROUND: The prevalence of cigarette use in people with HIV (PWH) is 2-3 times higher than the general population. Cigarette use increases risk of myocardial infarction (MI). Faster nicotine metabolism, quantified by the nicotine metabolite ratio (NMR) is associated with greater risk …

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MRI-Derived Body Composition and Breast Cancer Risk in Postmenopausal Women: UK Biobank Study

Livingstone Aduse‐Poku, Lusine Yaghjyan, Stephen E. Kimmel, Susmita Datta et autres

Background: Obesity is a risk factor for breast cancer mortality in postmenopausal women. However, it remains unclear which specific components of adipose tissue and skeletal muscle are associated with risk. This study assessed the associations between MRI-assessed adiposity, skeletal mass, and breast …

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Incorporating preprints in systematic reviews: a preliminary study of a novel method for rapid evidence synthesis

Jiayi Tong, Yifei Sun, Rebecca A. Hubbard, M. Elle Saine et autres

OBJECTIVES: By October 1, 2024, over 450,000 COVID-19 manuscripts were published, with 10% posted as unreviewed preprints. While they accelerate knowledge sharing, their inconsistent quality complicates systematic studies. MATERIALS AND METHODS: We propose a 2-stage method to include preprints in meta-analyses. In …

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Incorporating Preprints in Systematic Reviews: A Preliminary Study of a Novel Method for Rapid Evidence Synthesis

Jiayi Tong, Yifei Sun, Rebecca A. Hubbard, M. Elle Saine et autres

Objectives: By October 1, 2024, over 450,000 COVID-19 manuscripts were published, with 10% posted as unreviewed preprints. While they accelerate knowledge sharing, their inconsistent quality complicates systematic studies. Materials and Methods: We propose a two-stage method to include preprints in meta-analyses. In …

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Clinical outcomes of pharmacological therapies for heart failure in Black vs. White populations: a meta-analysis of randomized controlled trials of heart failure treatment

Yujia Li, Huilin Tang, Wenxi Huang, Wei‐Han Chen et autres

Objective To evaluate the effect of different pharmacological therapies for heart failure (HF) between the Black vs. White population. Method We included randomized controlled trials (RCT) of HF pharmacological therapies with explicit strata of Black or White adults in the primary or …

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Neighborhood Deprivation and Racial Disparities in Heart Failure Outcomes

Wenxi Huang, Yuru Zhu, Stephen E. Kimmel, Mustafa M. Ahmed et autres

BACKGROUND: Heart failure (HF) is a major contributor to hospitalizations and mortality in the United States, with significant racial disparities in care access and clinical outcomes. Social determinants of health (SDoH) play a critical role in shaping these disparities. OBJECTIVES: This study …

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Impact of Pre-Existing Frailty on Cardiotoxicity Among Breast Cancer Patients Receiving Adjuvant Therapy

Shuang Yang, Xiwei Lou, Mustafa M. Ahmed, Stephen E. Kimmel et autres

BACKGROUND: Prior research suggests that breast cancer patients with a high burden of frailty may face an increased risk of cardiotoxicity. OBJECTIVES: This study sought to examine the association between frailty and cardiotoxicity rates in female breast cancer patients receiving adjuvant therapy …

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Sodium-glucose cotransporter-2 inhibitors and incidence of atrial fibrillation in older adults with type 2 diabetes: a retrospective cohort analysis

Yujia Li, Huilin Tang, Yi Guo, Hui Shao et autres

Objectives To investigate the risk of atrial fibrillation (AF) with sodium-glucose cotransporter-2 inhibitors (SGLT2is) compared to dipeptidyl peptidase-4 inhibitor (DPP4i) use in older US adults and across diverse subgroups. Methods We conducted a retrospective cohort analysis using claims data from 15% random …

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Trajectories of Sacubitril/Valsartan Adherence Among Medicare Beneficiaries With Heart Failure

Wenxi Huang, Mustafa M. Ahmed, Earl J. Morris, Lanting Yang et autres

Background: Sacubitril/valsartan, an angiotensin receptor/neprilysin inhibitor (ARNi), improves heart failure (HF) outcomes, yet real-world adherence patterns are not well understood. Objectives: The purpose of this study was to analyze longitudinal patterns of adherence to ARNis in patients with HF and to identify …

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TRENDS AND OUTCOMES OF TRANSESOPHAGEAL ECHOCARDIOGRAM-GUIDED CARDIOVERSION IN PATIENTS WITH ATRIAL FIBRILLATION

Madeline Smoot, Chen Bai, Mohammad Al‐Ani, Stephen E. Kimmel et autres

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Comparable Cardiorenal Benefits of SGLT2 Inhibitors and GLP1RAs in Asian and White Populations: An Updated Meta-analysis of Results From Randomized Outcome Trials

Huilin Tang, Stephen E. Kimmel, Steven M. Smith, Kenneth Cusi et autres

BACKGROUND Whether the cardiorenal benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are comparable between White and Asian populations remains unclear. PURPOSE To compare the cardiorenal benefits of SGLT2 inhibitors and GLP-1RAs between White and Asian …

Comparable Cardiorenal Benefits of SGLT2 Inhibitors and GLP1RAs in Asian and White Populations: An Updated Meta-analysis of Results From Randomized Outcome Trials

Huilin Tang, Stephen E. Kimmel, Steven M. Smith, Kenneth Cusi et autres

BACKGROUND Whether the cardiorenal benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are comparable between White and Asian populations remains unclear. PURPOSE To compare the cardiorenal benefits of SGLT2 inhibitors and GLP-1RAs between White and Asian …