Accès ouvert
2026
article
OpenAlex
Hidetoshi Hayashi, Byoung Chul Cho, Yu Jung Kim, Se-Hoon Lee et autres
BACKGROUND: Approximately 60 % of lung cancer cases occur in Asia, indicating an epidemiological disparity and need for effective therapies. Amivantamab-lazertinib is approved for first-line EGFR-mutated advanced non-small cell lung cancer (NSCLC) in many countries. In the protocol-specified final overall survival (OS) …
jp, kr, th, my, cn, tw, tr, in, us
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2025
article
OpenAlex
James Chih‐Hsin Yang, Shun Lu, Hidetoshi Hayashi, Enriqueta Felip et autres
BACKGROUND: (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported. METHODS: -mutated (exon 19 deletion or L858R substitution), …
tw, cn, jp, es, us, fr, kr, ua, th, my, ar, br, it, de, au, in, mx, pt, ru, tr, gb, ca
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Accès ouvert
2024
article
OpenAlex
Byoung Chul Cho, Shun Lu, Enriqueta Felip, Alexander I. Spira et autres
Background Amivantamab plus lazertinib (amivantamab–lazertinib) has shown clinically meaningful and durable antitumor activity in patients with previously untreated or osimertinib-pretreated EGFR (epidermal growth factor receptor)–mutated advanced non–small-cell lung cancer (NSCLC). Methods In a phase 3, international, randomized trial, we assigned, in a …
cn, us, kr
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Accès ouvert
2019
article
OpenAlex
Gwo Fuang Ho, Chee-Shee Chai, Adlinda Alip, Mohd Ibrahim A. Wahid et autres
BACKGROUND: This study aimed to evaluate the efficacy, side-effects and resistance mechanisms of first-line afatinib in a real-world setting. METHODS: This is a multicenter observational study of first-line afatinib in Malaysian patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small cell lung …
my
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Accès ouvert
2018
article
OpenAlex
Sheila Nathan, Sylvia Chieng, Paul Vijay Kingsley, Anand Mohan et autres
Malaysia is an endemic hot spot for melioidosis; however, a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies, …
my
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Accès ouvert
2012
article
OpenAlex
Yeh Chunn Kuan, Soon-Hin How, AbdulAziz Azian, Chong Kin Liam et autres
INTRODUCTION: Prolonged use of oral corticosteroids is a risk factor for osteoporosis. However, the effect of inhaled corticosteroids (ICS) on bone mineral density (BMD) of asthmatic patients remains controversial. OBJECTIVES: We aimed to determine the prevalence of osteopenia and osteoporosis in our …
my
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